ALPK1 signaling pathway
Hu X, Yang C, Wang PG, Zhang GL. ADP-heptose: A new innate immune modulator. Carbohydr Res. 2019 Feb 01;473():123–8. doi: 10.1016/j.carres.2018.12.011. PMID: 30684847.; García-Weber D, Dangeard A, Cornil J, Thai L, Rytter H, Zamyatina A, Mulard LA, Arrieumerlou C. ADP-heptose is a newly identified pathogen-associated molecular pattern of Shigella flexneri. EMBO Reports. 2018 Nov 19;19(12). doi: 10.15252/embr.201846943.; Zhou P, She Y, Dong N, Li P, He H, Borio A, Wu Q, Lu S, Ding X, Cao Y, Xu Y, Gao W, Dong M, Ding J, Wang DC, Zamyatina A, Shao F. Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose. Nature. 2018 Sep;561(7721):122–6. doi: 10.1038/s41586-018-0433-3. PMID: 30111836.; Gall A, Gaudet RG, Gray-Owen SD, Salama NR. TIFA Signaling in Gastric Epithelial Cells Initiates thecagType 4 Secretion System-Dependent Innate Immune Response toHelicobacter pyloriInfection. mBio. 2017 Sep 06;8(4). doi: 10.1128/mbio.01168-17.; Zimmermann S, Pfannkuch L, Al-Zeer MA, Bartfeld S, Koch M, Liu J, Rechner C, Soerensen M, Sokolova O, Zamyatina A, Kosma P, Mäurer AP, Glowinski F, Pleissner KP, Schmid M, Brinkmann V, Karlas A, Naumann M, Rother M, Machuy N, Meyer TF. ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System. Cell Rep. 2017 Sep 05;20(10):2384–95. doi: 10.1016/j.celrep.2017.08.039. PMID: 28877472.; Stein SC, Faber E, Bats SH, Murillo T, Speidel Y, Coombs N, Josenhans C. Helicobacter pylori modulates host cell responses by CagT4SS-dependent translocation of an intermediate metabolite of LPS inner core heptose biosynthesis. PLoS Pathog. 2017 Jul 17;13(7):e1006514. doi: 10.1371/journal.ppat.1006514.; Gaudet RG, Guo CX, Molinaro R, Kottwitz H, Rohde JR, Dangeard AS, Arrieumerlou C, Girardin SE, Gray-Owen SD. Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway. Cell Rep. 2017 May 16;19(7):1418–30. doi: 10.1016/j.celrep.2017.04.063. PMID: 28514661.; Milivojevic M, Dangeard A, Kasper CA, Tschon T, Emmenlauer M, Pique C, Schnupf P, Guignot J, Arrieumerlou C. ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria. PLoS Pathog. 2017 Feb 21;13(2):e1006224. doi: 10.1371/journal.ppat.1006224.; Gaudet RG, Sintsova A, Buckwalter CM, Leung N, Cochrane A, Li J, Cox AD, Moffat J, Gray-Owen SD. INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity. Science. 2015 Jun 12;348(6240):1251–5. doi: 10.1126/science.aaa4921. PMID: 26068852.; Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P, Hu L, Shao F. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature. 2014 Oct 09;514(7521):187–92. doi: 10.1038/nature13683. PMID: 25119034.; Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, Newton K, Qu Y, Liu J, Heldens S, Zhang J, Lee WP, Roose-Girma M, Dixit VM. Non-canonical inflammasome activation targets caspase-11. Nature. 2011 Oct 16;479(7371):117–21. doi: 10.1038/nature10558. PMID: 22002608.; Ea CK, Sun L, Inoue J, Chen ZJ. TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15318–23. PMID: 15492226; PMCID: PMC524439.; Akashi S, Saitoh S, Wakabayashi Y, Kikuchi T, Takamura N, Nagai Y, Kusumoto Y, Fukase K, Kusumoto S, Adachi Y, Kosugi A, Miyake K. Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J Exp Med. 2003 Oct 06;198(7):1035–42. PMID: 14517279; PMCID: PMC2194215.