Diseases of programmed cell death

Ichim G, Tait SW. A fate worse than death: apoptosis as an oncogenic process. Nat Rev Cancer. 2016 Aug;16(8):539–48. doi: 10.1038/nrc.2016.58. PMID: 27364482.; Fernald K, Kurokawa M. Evading apoptosis in cancer. Trends in Cell Biology. 2013 Dec;23(12):620–33. doi: 10.1016/j.tcb.2013.07.006.; Chao MP, Majeti R, Weissman IL. Programmed cell removal: a new obstacle in the road to developing cancer. Nat Rev Cancer. 2011 Dec 08;12(1):58–67. doi: 10.1038/nrc3171. PMID: 22158022.; Wong RS. Apoptosis in cancer: from pathogenesis to treatment. Journal of Experimental & Clinical Cancer Research. 2011 Sep 26;30(1):87. doi: 10.1186/1756-9966-30-87.; Ghavami S, Hashemi M, Ande SR, Yeganeh B, Xiao W, Eshraghi M, Bus CJ, Kadkhoda K, Wiechec E, Halayko AJ, Los M. Apoptosis and cancer: mutations within caspase genes. J Med Genet. 2009 Aug;46(8):497–510. doi: 10.1136/jmg.2009.066944. PMID: 19505876.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Decitabine

Formula: C8H12N4O4 (228.08585119999998)

CAS ID: 2353-33-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
1.11.1.24 thioredoxin-dependent peroxiredoxin thioredoxin:hydroperoxide oxidoreductase
1.15.1.1 superoxide dismutase superoxide:superoxide oxidoreductase
1.17.4.1 ribonucleoside-diphosphate reductase 2'-deoxyribonucleoside-5'-diphosphate:thioredoxin-disulfide 2'-oxidoreductase
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.7.102 DNA primase AEP (deoxy)nucleotide 5'-triphosphate:single-stranded DNA (deoxy)nucleotidyltransferase (DNA or DNA-RNA hybrid synthesizing)
2.7.7.7 DNA-directed DNA polymerase deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase
3.4.22.52 calpain-1
3.4.22.53 calpain-2
3.4.22.61 caspase-8


Proteins

Protein ID name full name