phosphopantothenate biosynthesis I
Olzhausen J, Schübbe S, Schüller HJ. Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Curr Genet. 2009 Apr;55(2):163–73. doi: 10.1007/s00294-009-0234-1. PMID: 19266201.; White WH, Gunyuzlu PL, Toyn JH. Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. J Biol Chem. 2001 Apr 06;276(14):10794–800. doi: 10.1074/jbc.m009804200. PMID: 11154694.; Begley TP, Kinsland C, Strauss E. The biosynthesis of coenzyme A in bacteria. Vitam Horm. 2001;61():157–71. doi: 10.1016/s0083-6729(01)61005-7. PMID: 11153265.; Shimoi H, Okuda M, Ito K. Molecular cloning and application of a gene complementing pantothenic acid auxotrophy of sake yeast kyokai no. 7. Journal of Bioscience and Bioengineering. 2000 Jan;90(6):643–7. doi: 10.1016/s1389-1723(00)90010-0.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 3.1.3.- | |||
| 1.1.1.169 | 2-dehydropantoate 2-reductase | (R)-pantoate:NADP+ 2-oxidoreductase | |
| 1.1.1.86 | ketol-acid reductoisomerase (NADP+) | (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) | |
| 2.1.2.11 | 3-methyl-2-oxobutanoate hydroxymethyltransferase | 5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase | |
| 2.7.1.33 | pantothenate kinase | ATP:(R)-pantothenate 4'-phosphotransferase | |
| 6.3.2.1 | pantoate-beta-alanine ligase (AMP-forming) | (R)-pantoate:beta-alanine ligase (AMP-forming) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P05793 | ilvC | Ketol-acid reductoisomerase (NADP(+)) |
| P0A6I3 | coaA | Pantothenate kinase |
| P0A9J4 | panE | 2-dehydropantoate 2-reductase |
| P31057 | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase |
| P31663 | panC | Pantothenate synthetase |
| P38122 | ECM31 | 3-methyl-2-oxobutanoate hydroxymethyltransferase |
| P40459 | PAN6 | Pantoate--beta-alanine ligase |
| Q04430 | CAB1 | Pantothenate kinase CAB1 |