phosphopantothenate biosynthesis I

Olzhausen J, Schübbe S, Schüller HJ. Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Curr Genet. 2009 Apr;55(2):163–73. doi: 10.1007/s00294-009-0234-1. PMID: 19266201.; White WH, Gunyuzlu PL, Toyn JH. Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. J Biol Chem. 2001 Apr 06;276(14):10794–800. doi: 10.1074/jbc.m009804200. PMID: 11154694.; Begley TP, Kinsland C, Strauss E. The biosynthesis of coenzyme A in bacteria. Vitam Horm. 2001;61():157–71. doi: 10.1016/s0083-6729(01)61005-7. PMID: 11153265.; Shimoi H, Okuda M, Ito K. Molecular cloning and application of a gene complementing pantothenic acid auxotrophy of sake yeast kyokai no. 7. Journal of Bioscience and Bioengineering. 2000 Jan;90(6):643–7. doi: 10.1016/s1389-1723(00)90010-0.

Metabolites

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

Formaldehyde

Formula: CH2O (30.0105642)

CAS ID: 50-00-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

3-Methylbutan-2-one

Formula: C5H10O (86.07316100000001)

CAS ID: 563-80-4

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

hexadecanoate

Formula: C16H31O2 (255.2323926)

CAS ID: 143-20-4

isovalerate

Formula: C5H9O2 (101.0602514)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
3.1.3.-
1.1.1.169 2-dehydropantoate 2-reductase (R)-pantoate:NADP+ 2-oxidoreductase
1.1.1.86 ketol-acid reductoisomerase (NADP+) (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase 5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase
2.7.1.33 pantothenate kinase ATP:(R)-pantothenate 4'-phosphotransferase
6.3.2.1 pantoate-beta-alanine ligase (AMP-forming) (R)-pantoate:beta-alanine ligase (AMP-forming)


Proteins

Protein ID name full name
P05793 ilvC Ketol-acid reductoisomerase (NADP(+))
P0A6I3 coaA Pantothenate kinase
P0A9J4 panE 2-dehydropantoate 2-reductase
P31057 panB 3-methyl-2-oxobutanoate hydroxymethyltransferase
P31663 panC Pantothenate synthetase
P38122 ECM31 3-methyl-2-oxobutanoate hydroxymethyltransferase
P40459 PAN6 Pantoate--beta-alanine ligase
Q04430 CAB1 Pantothenate kinase CAB1