purine nucleotides de novo biosynthesis

Zhao H, French JB, Fang Y, Benkovic SJ. The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans. Chem Commun (Camb). 2013 May 18;49(40):4444–52. PMID: 23575936; PMCID: PMC3877848.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

butenedioate

Formula: C4H2O4 (113.99530920000001)

CAS ID: 17013-01-3

L-aspartate(1-)

Formula: C4H6NO4 (132.0296816)

CAS ID:

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)

Formula: C9H13N4O8P (336.0470988)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.-.-
1.1.1.205 IMP dehydrogenase IMP:NAD+ oxidoreductase
1.17.4.1 ribonucleoside-diphosphate reductase 2'-deoxyribonucleoside-5'-diphosphate:thioredoxin-disulfide 2'-oxidoreductase
2.1.2.2 phosphoribosylglycinamide formyltransferase 1 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase
2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase
2.4.2.14 amidophosphoribosyltransferase 5-phospho-beta-D-ribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
2.7.13.3 histidine kinase ATP:protein-L-histidine N-phosphotransferase
2.7.4.10 nucleoside-triphosphate-adenylate kinase nucleoside-triphosphate:AMP phosphotransferase
2.7.4.3 adenylate kinase ATP:AMP phosphotransferase
2.7.4.4 nucleoside-phosphate kinase ATP:nucleoside-phosphate phosphotransferase
2.7.4.6 nucleoside-diphosphate kinase ATP:nucleoside-diphosphate phosphotransferase
2.7.4.8 guanylate kinase ATP:(d)GMP phosphotransferase
3.5.4.10 IMP cyclohydrolase IMP 1,2-hydrolase (decyclizing)
4.1.1.21 phosphoribosylaminoimidazole carboxylase 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]
4.3.2.2 adenylosuccinate lyase N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
6.3.4.13 phosphoribosylamine-glycine ligase 5-phospho-D-ribosylamine:glycine ligase (ADP-forming)
6.3.4.4 adenylosuccinate synthase IMP:L-aspartate ligase (GDP-forming)
6.3.5.2 GMP synthase (glutamine-hydrolysing) xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)
6.3.5.3 phosphoribosylformylglycinamidine synthase N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)


Proteins

Protein ID name full name