rosmarinic acid biosynthesis I

Vogelsang K, Schneider B, Petersen M. Production of rosmarinic acid and a new rosmarinic acid 3'-O-beta-D-glucoside in suspension cultures of the hornwort Anthoceros agrestis Paton. Planta. 2006 Jan;223(2):369–73. doi: 10.1007/s00425-005-0089-8. PMID: 16133208.; Kim KH, Janiak V, Petersen M. Purification, cloning and functional expression of hydroxyphenylpyruvate reductase involved in rosmarinic acid biosynthesis in cell cultures of Coleus blumei. Plant Mol Biol. 2004 Feb;54(3):311–23. doi: 10.1023/b:plan.0000036367.03056.b2. PMID: 15284489.; Petersen M. Cinnamic acid 4-hydroxylase from cell cultures of the hornwort Anthoceros agrestis. Planta. 2003 May;217(1):96–101. doi: 10.1007/s00425-002-0960-9. PMID: 12721853.; Petersen M, Simmonds MS. Rosmarinic acid. Phytochemistry. 2003 Jan;62(2):121–5. doi: 10.1016/s0031-9422(02)00513-7. PMID: 12482446.; Matsuno M, Nagatsu A, Ogihara Y, Ellis BE, Mizukami H. CYP98A6 from Lithospermum erythrorhizon encodes 4-coumaroyl-4'-hydroxyphenyllactic acid 3-hydroxylase involved in rosmarinic acid biosynthesis1. FEBS Letters. 2002 Mar 13;514(2-3):219–24. doi: 10.1016/s0014-5793(02)02368-2.; Ellis BE, Towers GH. Biogenesis of rosmarinic acid in Mentha. Biochem J. 1970 Jun;118(2):291–7. PMID: 5484678; PMCID: PMC1179116.

Metabolites

Ancymidol

Formula: C15H16N2O2 (256.12117159999997)

CAS ID: 12771-68-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Methyl jasmonate

Formula: C13H20O3 (224.14123700000002)

CAS ID: 1211-29-6

Metyrapone

Formula: C14H14N2O (226.1106074)

CAS ID: 54-36-4

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

p-Coumaroyl-CoA

Formula: C30H42N7O18P3S (913.1519822000001)

CAS ID: 119785-99-8

Miconazole

Formula: C18H14Cl4N2O (413.9860194)

CAS ID: 22916-47-8

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

3-(4-hydroxyphenyl)pyruvate

Formula: C9H7O4 (179.0344322)

CAS ID: 622-54-8

cinnamate

Formula: C9H7O2 (147.0446022)

CAS ID: 4151-45-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

tetcyclacis

Formula: C13H12N5Cl1 (273.0781182)

CAS ID: 65245-23-0



Enzyme

EC Number name full name note


Proteins

Protein ID name full name