L-isoleucine biosynthesis I (from threonine)

Halgand F, Wessel PM, Laprévote O, Dumas R. Biochemical and mass spectrometric evidence for quaternary structure modifications of plant threonine deaminase induced by isoleucine. Biochemistry. 2002 Nov 19;41(46):13767–73. doi: 10.1021/bi0262348. PMID: 12427039.; Diebold R, Schuster J, Däschner K, Binder S. The branched-chain amino acid transaminase gene family in Arabidopsis encodes plastid and mitochondrial proteins. Plant Physiol. 2002 Jun;129(2):540–50. PMID: 12068099; PMCID: PMC161671.; Mourad G, Williams D, King J. A double mutant allele, csr1-4, of Arabidopsis thaliana encodes an acetolactate synthase with altered kinetics. Planta. 1995;196(1):64–8. doi: 10.1007/bf00193218. PMID: 7767237.; Mourad G, King J. L-O-Methylthreonine-Resistant Mutant of Arabidopsis Defective in Isoleucine Feedback Regulation. Plant Physiol. 1995 Jan;107(1):43–52. PMID: 12228340; PMCID: PMC161166.; Smith JK, Schloss JV, Mazur BJ. Functional expression of plant acetolactate synthase genes in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 1989 Jun;86(11):4179–83. doi: 10.1073/pnas.86.11.4179.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
2.2.1.6 acetolactate synthase pyruvate:pyruvate acetaldehydetransferase (decarboxylating)
2.6.1.42 branched-chain-amino-acid transaminase branched-chain-amino-acid:2-oxoglutarate aminotransferase
2.6.1.88 methionine transaminase L-methionine:2-oxo-acid aminotransferase


Proteins

Protein ID name full name