superpathway of leucine, valine, and isoleucine biosynthesis

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.85 3-isopropylmalate dehydrogenase (2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
1.1.1.86 ketol-acid reductoisomerase (NADP+) (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
2.2.1.6 acetolactate synthase pyruvate:pyruvate acetaldehydetransferase (decarboxylating)
2.3.3.13 2-isopropylmalate synthase acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
2.6.1.107 beta-methylphenylalanine transaminase (2S,3S)-3-methylphenylalanine:2-oxoglutarate aminotransferase
2.6.1.42 branched-chain-amino-acid transaminase branched-chain-amino-acid:2-oxoglutarate aminotransferase
2.6.1.57 aromatic-amino-acid transaminase aromatic-amino-acid:2-oxoglutarate aminotransferase
4.2.1.33 3-isopropylmalate dehydratase (2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
4.2.1.9 dihydroxy-acid dehydratase 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming)
4.3.1.17 L-serine ammonia-lyase L-serine ammonia-lyase (pyruvate-forming)
4.3.1.19 threonine ammonia-lyase L-threonine ammonia-lyase (2-oxobutanoate-forming)


Proteins

Protein ID name full name
P00893 ilvI Acetolactate synthase isozyme 3 large subunit
P00894 ilvH Acetolactate synthase isozyme 3 small subunit
P04693 tyrB Aromatic-amino-acid aminotransferase
P04968 ilvA L-threonine dehydratase biosynthetic IlvA
P05791 ilvD Dihydroxy-acid dehydratase
P05793 ilvC Ketol-acid reductoisomerase (NADP(+))
P08142 ilvB Acetolactate synthase isozyme 1 large subunit
P09151 leuA 2-isopropylmalate synthase
P0A6A6 leuC 3-isopropylmalate dehydratase large subunit
P0AB80 ilvE Branched-chain-amino-acid aminotransferase
P0ADF8 ilvN Acetolactate synthase isozyme 1 small subunit
P0ADG1 ilvM Acetolactate synthase isozyme 2 small subunit
P0AGF6 tdcB L-threonine dehydratase catabolic TdcB
P30125 leuB 3-isopropylmalate dehydrogenase
P30126 leuD 3-isopropylmalate dehydratase small subunit