3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al (BioCAD00000004065)

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Metabolite Card

Formula: C21H32O5 (364.225)
SMILES: CC12CC[C@@H](O)CC1CCC1C3CCC(C(=O)CO)C3(CC(O)C21)C=O

Synonyms [en]

3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al; 3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al; (3R,5R,8S,9S,10S,11S,14S)-3,11-dihydroxy-17-(2-hydroxyacetyl)-10-methyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-13-carbaldehyde; (5R)-5,17-dihydroxy-14-(2-hydroxyacetyl)-2-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane-15-carbaldehyde; 5beta-pregnane-3alpha,11beta,21-triol-20-one-18-al; Tetrahydroaldosterone

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000004065). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al is an intermediate in C21-Steroid hormone metabolism. 3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al is converted from 11beta,21-Dihydroxy-3,20-oxo-5beta-pregnan-18-al via the enzyme 3-alpha-hydroxysteroid dehydrogenase (EC 1.1.1.50).

Extracellular Membrane
Entity Information

DBLinks

Other DBLinks
  • PubChem: 13847328
  • PubChem: 440695
  • PubChem: 44263346
  • ChEBI: ChEBI:1684
  • ChEBI: ChEBI:171956
  • HMDB: HMDB0006753
  • HMDB: HMDB06753
  • LipidMaps: LMST02030197
  • LipidMaps: LMST02030275
  • KEGG: C05474
  • RefMet: RM0128393
  • Metlin: METLIN_57884

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R04835 1.1.1.50 3alpha,11beta,21-trihydroxy-20-oxo-5beta-pregnan-18-al:NAD+ oxidoreductase (B-specific)
KEGG:R04836 1.1.1.50 3alpha,11beta,21-trihydroxy-20-oxo-5beta-pregnan-18-al:NADP+ oxidoreductase (B-specific)
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
WikiPathways:WP3604 Biochemical pathways: part I
PathBank:SMP0120690 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
PathBank:SMP0120858 11-beta-Hydroxylase Deficiency (CYP11B1)
PathBank:SMP0120641 Corticosterone Methyl Oxidase I Deficiency (CMO I)
PathBank:SMP0120649 Apparent Mineralocorticoid Excess Syndrome
PathBank:SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
PathBank:SMP0000576 21-Hydroxylase Deficiency (CYP21)
PathBank:SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency
PathBank:SMP0087238 Steroidogenesis
PathBank:SMP0120849 17-alpha-Hydroxylase Deficiency (CYP17)
PathBank:SMP0120861 Corticosterone Methyl Oxidase II Deficiency (CMO II)
PathBank:SMP0120869 3-beta-Hydroxysteroid Dehydrogenase Deficiency
PathBank:SMP0120451 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency
PathBank:SMP0120640 21-Hydroxylase Deficiency (CYP21)
PathBank:SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1)
PathBank:SMP0000717 Apparent Mineralocorticoid Excess Syndrome
PathBank:SMP0063672 Steroidogenesis
PathBank:SMP0120672 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency
PathBank:SMP0120860 Corticosterone Methyl Oxidase I Deficiency (CMO I)
PathBank:SMP0120868 Apparent Mineralocorticoid Excess Syndrome
View All Pathways