2,5-Dihydroxypyridine (BioCAD00000003057)

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Metabolite Card

Formula: C5H5NO2 (111.032)
SMILES: Oc1ccc(O)nc1

Synonyms [en]

2,5-dihydroxypyridine; 5-hydroxy-2(1H)-pyridinone; pyridine-2,5-diol; 5-hydroxy-1H-pyridin-2-one; 5-oxidanyl-1H-pyridin-2-one; 5-Hydroxy-2-pyridone

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

2,5-Dihydroxypyridine. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000003057). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

A dihydroxypyridine that is pyridine substituted by hydroxy groups at positions 2 and 5." []

Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 24154-26-5
  • CAS Registry Number: 5154-01-8
  • CAS Registry Number: 84719-33-5
  • PubChem: 99456
  • ChEBI: ChEBI:16364
  • KEGG: C01059
  • BioCyc: 2-5-DIHYDROXYPYRIDINE
  • NCBI MeSH: 2,5-dihydroxypyridine
  • Coconut NaturalProduct: CNP0381187.0
  • Coconut NaturalProduct: CNP0491283.0

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R00047 1.14.99.- 6-hydroxynicotinate,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating, decarboxylating)
KEGG:R03204 2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase
KEGG:R03206 1.14.99.26 2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating)
KEGG:R08764 1.14.13.114 6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating)
KEGG:R09125 1.13.11.9 2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase
KEGG:R09472 1.14.13.163 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing)
Rhea:RHEA:16974 1.14.99.26 2-hydroxypyridine + AH2 + O2 => 2,5-dihydroxypyridine + A + H2O
Rhea:RHEA:16975 1.14.99.26 2,5-dihydroxypyridine + A + H2O => 2-hydroxypyridine + AH2 + O2
Rhea:RHEA:16976 1.14.99.26 2-hydroxypyridine + AH2 + O2 <=> 2,5-dihydroxypyridine + A + H2O
Rhea:RHEA:27334 1.14.13.114 6-hydroxynicotinate + NADH + O2 + 2 H+ => 2,5-dihydroxypyridine + CO2 + NAD+ + H2O
Rhea:RHEA:27335 1.14.13.114 2,5-dihydroxypyridine + CO2 + NAD+ + H2O => 6-hydroxynicotinate + NADH + O2 + 2 H+
Rhea:RHEA:27336 1.14.13.114 6-hydroxynicotinate + NADH + O2 + 2 H+ <=> 2,5-dihydroxypyridine + CO2 + NAD+ + H2O
Rhea:RHEA:27523 1.13.11.9 2,5-dihydroxypyridine + O2 => N-formylmaleamate + H+
Rhea:RHEA:27524 1.13.11.9 N-formylmaleamate + H+ => 2,5-dihydroxypyridine + O2
Rhea:RHEA:27525 1.13.11.9 2,5-dihydroxypyridine + O2 <=> N-formylmaleamate + H+
Rhea:RHEA:33928 1.14.13.163 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + O2 + 2 H+ => 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
Rhea:RHEA:33929 1.14.13.163 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O => 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + O2 + 2 H+
Rhea:RHEA:33930 1.14.13.163 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + O2 + 2 H+ <=> 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
BioCyc:RXN-7573 1.14.13.114 6-HYDROXY-NICOTINATE + NADH + 2 PROTON + OXYGEN-MOLECULE --> 2-5-DIHYDROXYPYRIDINE + NAD + CARBON-DIOXIDE + WATER
BioCyc:2-HYDROXYPYRIDINE-5-MONOOXYGENASE-RXN 1.14.99.26 OXYGEN-MOLECULE + Donor-H2 + 2-HYDROXYPYRIDINE --> 2-5-DIHYDROXYPYRIDINE + WATER + Acceptor
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Organism Source

Taxonomy Source

  1. Mus musculus [ncbi taxid: 10090]

Pathway Synthetic

pathway id name
BioCyc:META_PWY-5062 superpathway of nicotinate degradation
BioCyc:META_PWY-6993 nicotine degradation II (pyrrolidine pathway)
BioCyc:META_PWY-722 nicotinate degradation I
BioCyc:META_PWY-7128 nicotine degradation III (VPP pathway)
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