Salicylate (BioCAD00000017513)

blood feces saliva urine epidermis liver placenta

Metabolite Card

Formula: C7H6O3 (138.0317)
SMILES: OC(=O)C1=C(O)C=CC=C1

Synonyms [en]

Salicylic acid; Salicylate; 2-HYDROXYBENZOIC ACID; o-Hydroxybenzoic acid; 2-Carboxyphenol; Salicylic acid soap

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Salicylate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000017513). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Salicylic acid is a monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves. It has a role as an antiinfective agent, an antifungal agent, a keratolytic drug, an EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor, a plant metabolite, an algal metabolite and a plant hormone. It is a conjugate acid of a salicylate. It is a colorless solid, it is a precursor to and a metabolite of aspirin (acetylsalicylic acid). It is a plant hormone. The name is from Latin salix for willow tree. It is an ingredient in some anti-acne products. Salts and esters of salicylic acid are known as salicylates. Salicylic acid modulates COX1 enzymatic activity to decrease the formation of pro-inflammatory prostaglandins. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms. Salicylic acid works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for new cell growth. Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with nicotinamide adenosine dinucleotide and noncompetitively with UDPG. It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid to the phenolic acceptor. The wound-healing retardation action of salicylates is probably due mainly to its inhibitory action on mucopolysaccharide synthesis. Salicylic acid is biosynthesized from the amino acid phenylalanine. In Arabidopsis thaliana, it can be synthesized via a phenylalanine-independent pathway.

Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 29656-58-4
  • CAS Registry Number: 63-36-5
  • CAS Registry Number: 69-72-7
  • CAS Registry Number: 8042-60-2
  • CAS Registry Number: 8052-31-1
  • PubChem: 338
  • ChEBI: ChEBI:16914
  • HMDB: HMDB0001895
  • KEGG: C00805
  • BioCyc: CPD-110
  • NCBI MeSH: Salicylic Acid
  • Wikipedia: Salicylic acid
  • Wikipedia: Salicylic_Acid
  • DrugBank: DB00936
  • RefMet: RM0136132
  • MoNA: AU238262
  • MoNA: BAF_UVA_POS001512
  • MoNA: CCMSLIB00000078854
  • MoNA: CCMSLIB00005720556
  • MoNA: CCMSLIB00005720856
  • MoNA: EQ369601
  • MoNA: EQ369602
  • MoNA: EQ369603
  • MoNA: EQ369604
  • MoNA: EQ369605
  • MoNA: EQ369606
  • MoNA: EQ369607
  • MoNA: EQ369608
  • MoNA: EQ369609
  • MoNA: EQ369651
  • MoNA: EQ369652
  • MoNA: EQ369653
  • MoNA: EQ369654
  • MoNA: EQ369655
  • MoNA: EQ369656
  • MoNA: EQ369657
  • MoNA: EQ369658
  • MoNA: EQ369659
  • MoNA: FiehnHILIC001502
  • MoNA: FiehnHILIC002977
  • MoNA: FiehnLib000321
  • MoNA: HMDB0001895_c_ms_1206
  • MoNA: HMDB0001895_ms_ms_1810
  • MoNA: HMDB0001895_ms_ms_1811
  • MoNA: HMDB0001895_ms_ms_1812
  • MoNA: HMDB0001895_ms_ms_285555
  • MoNA: HMDB0001895_ms_ms_285556
  • MoNA: JP011792
  • MoNA: KO001003
  • MoNA: KO001004
  • MoNA: KO001005
  • MoNA: KO001006
  • MoNA: KO001007
  • MoNA: LU090951
  • MoNA: LU090952
  • MoNA: LU090953
  • MoNA: LU090954
  • MoNA: LU090955
  • MoNA: LU090956
  • MoNA: MetaboBASE0128
  • MoNA: MetaboBASE0129
  • MoNA: MoNA001264
  • MoNA: MoNA033524
  • MoNA: MoNA033525
  • MoNA: MoNA033526
  • MoNA: MoNA036336
  • MoNA: MoNA036339
  • MoNA: MoNA036340
  • MoNA: MoNA037318
  • MoNA: MoNA037666
  • MoNA: MoNA038812
  • MoNA: MoNA_0007309
  • MoNA: MoNA_0008804
  • MoNA: MoNA_0008805
  • MoNA: MoNA_0008806
  • MoNA: MoNA_0009506
  • MoNA: MoNA_0009507
  • MoNA: MoNA_0009508
  • MoNA: MoNA_0009509
  • MoNA: MoNA_0009510
  • MoNA: MoNA_0009511
  • MoNA: MoNA_0010044
  • MoNA: MoNA_0010045
  • MoNA: PS095907
  • MoNA: PS095908
  • MoNA: PS095909
  • MoNA: RP017001
  • MoNA: RP017002
  • MoNA: RP017003
  • MoNA: RP017011
  • MoNA: RP017012
  • MoNA: RP017013
  • MoNA: WA000472
  • MoNA: WA000473
  • MoNA: WA000474
  • MoNA: WA000475
  • Metlin: METLIN_616
  • Coconut NaturalProduct: CNP0230203.0

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R00818 1.14.13.1 salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
KEGG:R02941 1.2.1.65 salicylaldehyde:NAD+ oxidoreductase
KEGG:R02942 3.1.1.55 acetylsalicylate O-acetylhydrolase
KEGG:R05360 3.7.1.- C07731 + C00001<=>C00805 + C00596
KEGG:R05537 C01198 + C00002 + C00010 + C00016 + C00003<=>C00805 + C00020 + C00013 + C01352 + C00024 + C00004 + C00080
KEGG:R06602 4.2.99.21 isochorismate pyruvate-lyase (salicylate-forming)
KEGG:R06603 C00251<=>C00805 + C00022
KEGG:R06925 4.1.1.- C14097<=>C00805 + C00011
KEGG:R07695 C16213<=>C00805
KEGG:R07709 1.14.13.172 salicylate,NADH:oxygen oxidoreductase (5-hydroxylating)
KEGG:R07710 1.14.13.172 salicylate,NADPH:oxygen oxidoreductase (5-hydroxylating)
KEGG:R08838 1.14.13.- benzoate,NADPH:oxygen oxidoreductase (2-hydroxylating)
KEGG:R09539 4.1.1.91 salicylate carboxy-lyase
KEGG:R10448 2.1.1.274 S-adenosyl-L-methionine:salicylate 1-O-methyltransferase
KEGG:R12640 6.2.1.61 salicylate:CoA ligase (AMP-forming)
KEGG:R12642 6.2.1.65 salicylate:CoA ligase (AMP-forming)
KEGG:R12805 6.2.1.61 salicylate:holo-[non-ribosomal peptide synthase] ligase
BioCyc:RXN0-7384 CPLX0-7418 + CPD-110<=>CPLX0-8579
BioCyc:RXN0-290 PD00364 + CPD-110<=>MONOMER-58
BioCyc:RXN-11114 S-ADENOSYLMETHIONINE + CPD-110 + 2 CYS + NADPH --> CPD-9992 + ADENOSYL-HOMO-CYS + NADP + 4 WATER
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Organism Source

Taxonomy Source

  1. Abies alba Mill. [ncbi taxid: ]
  2. Abrus pulchellus [ncbi taxid: 192852]
  3. Achyranthes aspera [ncbi taxid: 240005]
  4. Aconitum carmichaelii [ncbi taxid: 85363]
  5. Aconitum coreanum [ncbi taxid: 662772]
  6. Aconitum japonicum [ncbi taxid: 1478108]
  7. Actaea dahurica [ncbi taxid: 64029]
  8. Actaea heracleifolia [ncbi taxid: 64034]
  9. Actaea simplex [ncbi taxid: 64042]
  10. Actinidia deliciosa [ncbi taxid: 3627]
  11. Alibertia sessilis [ncbi taxid: ]
  12. Alstonia muelleriana [ncbi taxid: 1382056]
  13. Amsinckia tessellata [ncbi taxid: 1037326]
  14. Anacardium occidentale [ncbi taxid: 171929]
  15. Anolis lineatopus [ncbi taxid: 75259]
  16. Arabidopsis thaliana [ncbi taxid: 3702]
  17. Artemisia annua [ncbi taxid: 35608]
  18. Artemisia annua L. [ncbi taxid: ]
  19. Artemisia capillaris [ncbi taxid: 265783]
  20. Artemisia cina [ncbi taxid: 1473222]
  21. Artemisia scoparia [ncbi taxid: 72351]
  22. Aspalathus linearis [ncbi taxid: 155124]
  23. Aspergillus mutabilis [ncbi taxid: ]
  24. Aucuba chinensis [ncbi taxid: 173669]
  25. Aurelia aurita [ncbi taxid: 6145]
  26. Bistorta vivipara [ncbi taxid: 371026]
  27. Bletilla striata [ncbi taxid: 78707]
  28. Brickellia vernicosa [ncbi taxid: 1550870]
  29. Broussonetia kazinoki [ncbi taxid: 66380]
  30. Broussonetia papyrifera [ncbi taxid: 172644]
  31. Burchardia multiflora [ncbi taxid: 244022]
  32. Callicarpa integerrima [ncbi taxid: 2825865]
  33. Carduus crispus [ncbi taxid: 324586]
  34. Carica dodecaphylla [ncbi taxid: ]
  35. Catharanthus roseus [ncbi taxid: 4058]
  36. Cedronella canariensis [ncbi taxid: 260595]
  37. Centaurea huber-morathii [ncbi taxid: ]
  38. Centella asiatica [ncbi taxid: 48106]
  39. Cephalotaxus fortunei [ncbi taxid: 66169]
  40. Cestrum nocturnum [ncbi taxid: 225615]
  41. Chlamydomonas reinhardtii [ncbi taxid: 3055]
  42. Cimicifuga foetida [ncbi taxid: ]
  43. Cinnamomum verum [ncbi taxid: 128608]
  44. Citrullus lanatus [ncbi taxid: 3654]
  45. Citrus paradisi [ncbi taxid: ]
  46. Citrus reticulata [ncbi taxid: 85571]
  47. Citrus tangerina [ncbi taxid: 237575]
  48. Citrus unshiu [ncbi taxid: 55188]
  49. Cordyceps sinensis [ncbi taxid: ]
  50. Coreopsis nodosa [ncbi taxid: ]
  51. Coriandrum sativum [ncbi taxid: 4047]
  52. Cossypium herbaceum [ncbi taxid: ]
  53. Crocus minimus [ncbi taxid: 481083]
  54. Crocus sativus [ncbi taxid: 82528]
  55. Cunonia macrophylla [ncbi taxid: 140420]
  56. Curculigo pilosa [ncbi taxid: 1037973]
  57. Curcuma longa [ncbi taxid: 136217]
  58. Cynanchum chinense [ncbi taxid: 755258]
  59. Cynometra lujae [ncbi taxid: 1971658]
  60. Dacrydium cupressinum [ncbi taxid: 56890]
  61. Diospyros kaki [ncbi taxid: 35925]
  62. Ecklonia kurome [ncbi taxid: ]
  63. Entada rheedei [ncbi taxid: 204974]
  64. Erylus trisphaerus [ncbi taxid: 2760685]
  65. Eupatorium areolare [ncbi taxid: ]
  66. Fagopyrum esculentum [ncbi taxid: 3617]
  67. Felimida luteorosea [ncbi taxid: 1499118]
  68. Flindersia laevicarpa C.T.White et Francis. [ncbi taxid: ]
  69. Foeniculum vulgare [ncbi taxid: ]
  70. FOOD SAKE [ncbi taxid: ]
  71. Fructus choerospondiatis [ncbi taxid: ]
  72. Fructus psoraleae corylifoliae [ncbi taxid: ]
  73. Gaultheria procumbens [ncbi taxid: 157519]
  74. Gaultheria yunnanensis [ncbi taxid: ]
  75. Gleditsia caspica [ncbi taxid: 66090]
  76. Glehnia littoralis [ncbi taxid: 48119]
  77. Glycine tomentella [ncbi taxid: 44015]
  78. Gossypium herbaceum [ncbi taxid: 34274]
  79. Gracilaria textorii [ncbi taxid: 172949]
  80. Haematococcus lacustris [ncbi taxid: 44745]
  81. Haplophyllum ramosissimum [ncbi taxid: 1006079]
  82. Harpephyllum caffrum [ncbi taxid: 289712]
  83. Helichrysum mixtum [ncbi taxid: 1442678]
  84. Herba artemisiae scopariae [ncbi taxid: ]
  85. Homo sapiens [ncbi taxid: 9606]
  86. Hordeum vulgare [ncbi taxid: 4513]
  87. Humata pectinata [ncbi taxid: ]
  88. Hydnellum zonatum [ncbi taxid: ]
  89. Hypoxylon rubiginosum [ncbi taxid: 110542]
  90. Imperata cylindrica var. major [ncbi taxid: 294751]
  91. Inula britannica [ncbi taxid: ]
  92. Isatis indigotica [ncbi taxid: 3242077]
  93. Isatis tinctoria [ncbi taxid: 161756]
  94. Isodon japonica var. glaucocalyx [ncbi taxid: ]
  95. Juglans regia [ncbi taxid: 51240]
  96. Kali turgidum [ncbi taxid: ]
  97. Laggera alata [ncbi taxid: 441197]
  98. Lysiana subfalcata [ncbi taxid: ]
  99. Macaranga peltata [ncbi taxid: 1398557]
  100. Malva silvestris [ncbi taxid: ]
  101. Mangifera indica [ncbi taxid: 29780]
  102. Melia azedarach [ncbi taxid: 155640]
  103. Melia azedarach var. toosendan [ncbi taxid: 71608]
  104. Menispermum dauricum [ncbi taxid: 49683]
  105. Mentha x piperita [ncbi taxid: 34256]
  106. Metagentiana rhodantha [ncbi taxid: 50767]
  107. Myristica fragrans [ncbi taxid: 51089]
  108. Nelumbo nucifera [ncbi taxid: 4432]
  109. Nicotiana undulata [ncbi taxid: 118713]
  110. Nidus vespae [ncbi taxid: ]
  111. Nostoc spongiaeforme [ncbi taxid: 502487]
  112. Orthantha lutea [ncbi taxid: ]
  113. Osteospermum muricatum [ncbi taxid: 41618]
  114. Paeonia rockii [ncbi taxid: 62886]
  115. Paeonia suffruticosa [ncbi taxid: 45171]
  116. Panax ginseng [ncbi taxid: 4054]
  117. Panax schinseng [ncbi taxid: ]
  118. Parablechnum minus [ncbi taxid: 393576]
  119. Passiflora incarnata [ncbi taxid: 159425]
  120. Peperomia vulcanica [ncbi taxid: 1719589]
  121. Phaeolus schweinitzii [ncbi taxid: 40476]
  122. Physalis edulis [ncbi taxid: ]
  123. Pinus edulis [ncbi taxid: 3340]
  124. Pinus radiata [ncbi taxid: 3347]
  125. Piptothrix pubens [ncbi taxid: ]
  126. Plantago major [ncbi taxid: 29818]
  127. Platycarya strobilacea [ncbi taxid: 91224]
  128. Polygonatum cyrtonema [ncbi taxid: 195526]
  129. Polygonatum falcatum [ncbi taxid: 261410]
  130. Polygonatum kingianum [ncbi taxid: 261420]
  131. Polygonatum sibiricum [ncbi taxid: 261423]
  132. Populus pseudosimonii [ncbi taxid: 2570303]
  133. Premna tomentosa [ncbi taxid: 2963287]
  134. Pseudomonas aeruginosa [ncbi taxid: 287]
  135. Pseudostellaria heterophylla [ncbi taxid: 418402]
  136. Pteris multifida [ncbi taxid: 170715]
  137. Pterocarya stenoptera [ncbi taxid: 91225]
  138. Pterocladiella tenuis [ncbi taxid: 947988]
  139. Punica granatum [ncbi taxid: 22663]
  140. Radix moghaniae philippinensis [ncbi taxid: ]
  141. Rehmannia glutinosa [ncbi taxid: 99300]
  142. Rhaponticum carthamoides [ncbi taxid: ]
  143. Rosa rugosa [ncbi taxid: 74645]
  144. Rosmarinus officinalis [ncbi taxid: ]
  145. Rubus chingii [ncbi taxid: 714495]
  146. Rubus coreanus [ncbi taxid: 321593]
  147. Rubus idaeus [ncbi taxid: 32247]
  148. Saccharina japonica [ncbi taxid: 88149]
  149. Saccharomyces pastori [ncbi taxid: ]
  150. Sagittaria sagittifolia [ncbi taxid: 4451]
  151. Salvia staminea [ncbi taxid: 268934]
  152. Sauromatum guttatum [ncbi taxid: ]
  153. Sauromatum venosum [ncbi taxid: 4463]
  154. Saussurea amara [ncbi taxid: 238930]
  155. Schisandra chinensis [ncbi taxid: 50507]
  156. Senecio paludaffinis [ncbi taxid: 1892289]
  157. Senna alexandrina [ncbi taxid: 72402]
  158. Sia ferox [ncbi taxid: ]
  159. Sideritis euboea [ncbi taxid: 155244]
  160. Sisyrinchium californicum [ncbi taxid: 915440]
  161. Sorbus tianschanica [ncbi taxid: 691244]
  162. Stephania elegans [ncbi taxid: 152364]
  163. Streptomyces flocculus [ncbi taxid: ]
  164. Streptomyces PM9 [ncbi taxid: ]
  165. Streptomyces scabies [ncbi taxid: ]
  166. Swertia angustifolia [ncbi taxid: 166611]
  167. Swertia swertopsis [ncbi taxid: ]
  168. Tabebuia avellanedae [ncbi taxid: ]
  169. Tachigalia paniculata [ncbi taxid: ]
  170. Taxodium distichum [ncbi taxid: 28982]
  171. Taxus baccata [ncbi taxid: 25629]
  172. Taxus brevifolia [ncbi taxid: 46220]
  173. Thymus vulgaris [ncbi taxid: 49992]
  174. Tournefortia sarmentosa [ncbi taxid: ]
  175. Trichoderma koningi [ncbi taxid: ]
  176. Trigonella grandiflora [ncbi taxid: 1210110]
  177. Tripolium pannonicum [ncbi taxid: 74787]
  178. Tsuga chinensis [ncbi taxid: 93694]
  179. Tulipa gesneriana [ncbi taxid: 13306]
  180. Usnea undulata [ncbi taxid: 2563878]
  181. Utricularia australis [ncbi taxid: 192276]
  182. Uvaria calamistrata [ncbi taxid: 672966]
  183. Vaccinium macrocarpon [ncbi taxid: 13750]
  184. Virgilia divaricata [ncbi taxid: 58850]
  185. Xanthium strumarium [ncbi taxid: 318068]
  186. Zingiber officinale [ncbi taxid: 94328]

Pathway Synthetic

pathway id name
WikiPathways:WP3622 AtMetExpress overview
PathBank:SMP0000709 Salicylic Acid Action Pathway
View All Pathways