Heparan sulfate (BioCAD00000012026)

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Metabolite Card

Formula: (C12H15NO10(R1)3(R2))n ()
SMILES: C([C@@H]1([C@H]([C@@H]([C@@H](NS([O-])(=O)=O)[C@H](O1)O[R2])O)O[C@H]2([C@@H]([C@H]([C@@H]([C@@H](C([O-])=O)O2)O[C@@H]3([C@H](NS([O-])(=O)=O)[C@H]([C@@H]([C@@H](CO)O3)O[C@H]4([C@@H]([C@H]([C@@H]([C@@H](C([O-])=O)O4)O[R1])O)O))O))O)O)))O

Synonyms [en]

Heparitin sulfate; Heparin sulfate; Heparan sulfate; Heparin monosulfate

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Heparan sulfate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000012026). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

|FRAME: Heparan-Sulfate "Heparan sulfate"| (also known as heparitin sulfate) is a member of the |FRAME: Glycosaminoglycans "glycosaminoglycan"| family. It consists of a variably sulfated repeating disaccharide unit composed of a hexuronic acid and a hexosamine.The most common repeating unit, which makes up around 50% of the total disaccharide units in heparan sulfate, is composed of |FRAME: CPD-12521| linked to |FRAME: CPD-12541|. In other units |FRAME: CPD-12521| may be substituted by |FRAME: CPD-12515| or its sulfated form |FRAME: CPD-12518|, and |FRAME: N-ACETYL-BETA-D-GLUCOSAMINE| may be sulfated to |FRAME: CPD-12565|, or may be substituted by |FRAME: N-sulfo-D-glucosamine| or |FRAME: CPD-12533|.Heparan sulfate binds to specific proteins such as antithrombin and several growth factors, thereby regulating various biological processes including anticoagulation and angiogenesis |CITS: [9151776]|. The unique sulfation pattern of a monosaccharide sequence within HS is believed to be critical for binding to the target protein.The structure of heparan sulfate is very similar to that of |FRAME: HEPARIN|. Heparan sulfate contains lower amounts of sulfate and less iduronic acid than heparin |CITS: [5484472]|. In addition, heparan sulfates disaccharide units are organized into distinct sulfated and non-sulfated domains, while heparin disaccharides are sulfated randomly |CITS: [15047699]|. |FRAME: Heparan-Sulfate "Heparan sulfate"| chains comprise three different types of domains: S-domains that contain contiguous N-sulfated residues, unmodified N-acetyl-rich regions, and mixed transition zones between the S-domains and the unmodified segments. Only the S-domains have binding capacities for growth factors and other proteins |CITS: [11489926]|.

Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 9050-30-0
  • ChEBI: ChEBI:28815
  • KEGG: C00925

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R07811 3.2.1.166 C00925 + C00001<=>C00925 + G13034
BioCyc:4.2.2.8-RXN 4.2.2.8 Heparan-Sulfate --> ∞ CPD-17702
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Organism Source

Taxonomy Source

Pathway Synthetic

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