dUMP (BioCAD00000010439)

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Metabolite Card

Formula: C9H13N2O8P (308.041)
SMILES: O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)N1C=CC(=O)NC1=O

Synonyms [en]

dUMP; Deoxyuridine monophosphate; Deoxyuridine 5'-phosphate; 2'-Deoxyuridine 5'-monophosphate; Deoxyuridylic acid; 2'-deoxyuridine 5'-phosphate

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

dUMP. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000010439). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Deoxyuridine monophosphate (dUMP), also known as deoxyuridylic acid or deoxyuridylate in its conjugate acid and conjugate base forms, respectively, is a deoxynucleotide. It belongs to the class of organic compounds known as pyrimidine 2'-deoxyribonucleoside monophosphates. These are pyrimidine nucleotides with a monophosphate group linked to the ribose moiety lacking a hydroxyl group at position 2. dUMP exists in all living species, ranging from bacteria to humans. Within humans, dUMP participates in a number of enzymatic reactions. In particular, dUMP can be biosynthesized from dCMP through its interaction with the enzyme deoxycytidylate deaminase. In addition, dUMP can be biosynthesized from deoxyuridine; which is mediated by the enzyme thymidine kinase, cytosolic. In humans, dUMP is involved in pyrimidine metabolism. A pyrimidine 2'-deoxyribonucleoside 5'-monophosphate having uracil as the nucleobase. Outside of the human body, dUMP has been detected, but not quantified in several different foods, such as breadnut tree seeds, sea-buckthornberries, sour cherries, black walnuts, and common oregano.

Mitochondria Nucleus
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 42155-08-8
  • CAS Registry Number: 964-26-1
  • PubChem: 65063
  • ChEBI: ChEBI:17622
  • HMDB: HMDB0001409
  • KEGG: C00365
  • BioCyc: DUMP
  • NCBI MeSH: 2'-deoxyuridylic acid
  • Wikipedia: Deoxyuridine_monophosphate
  • DrugBank: DB03800
  • RefMet: RM0136095
  • MoNA: CCMSLIB00005720730
  • MoNA: FiehnHILIC001146
  • MoNA: FiehnHILIC001873
  • MoNA: FiehnHILIC002449
  • MoNA: HMDB0001409_ms_ms_1562
  • MoNA: HMDB0001409_ms_ms_1563
  • MoNA: HMDB0001409_ms_ms_1564
  • MoNA: MoNA001953
  • MoNA: MoNA001954
  • MoNA: MoNA001955
  • MoNA: MoNA032140
  • MoNA: MoNA032141
  • MoNA: MoNA032143
  • MoNA: MoNA034091
  • MoNA: MoNA034093
  • MoNA: MoNA034094
  • MoNA: MoNA036064
  • MoNA: MoNA036066
  • MoNA: MoNA036067
  • MoNA: MoNA037180
  • MoNA: MoNA038437
  • MoNA: MoNA038569
  • MoNA: PR100526
  • MoNA: PS015101
  • MoNA: PS015102
  • MoNA: PS015103
  • MoNA: PS015104
  • MoNA: PS015105
  • MoNA: PS015106
  • MoNA: PS015107
  • MoNA: PS015108
  • MoNA: PS015109
  • Metlin: METLIN_3440
  • Metlin: METLIN_4140
  • Coconut NaturalProduct: CNP0415783.1

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R01663 3.5.4.12 dCMP aminohydrolase
KEGG:R02098 2.7.4.4 ATP:dUMP phosphotransferase
KEGG:R02099 2.7.1.21 ATP:deoxyuridine 5'-phosphotransferase
KEGG:R02100 3.6.1.23 dUTP nucleotidohydrolase
KEGG:R02101 2.1.1.45 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
KEGG:R02102 3.1.3.5 2'-deoxyuridine 5'-monophosphate phosphohydrolase
KEGG:R06613 2.1.1.148 5,10-methylenetetrahydrofolate,NADPH:dUMP C-methyltransferase
KEGG:R07307 3.5.4.30 dCTP aminohydrolase (dUMP-forming)
BioCyc:RXN-8850 2.1.1.148 DUMP + METHYLENE-THF-GLU-N + NADPH + PROTON --> TMP + THF-GLU-N + NADP
BioCyc:DURIDKI-RXN 2.7.1.145 DEOXYURIDINE + ATP --> PROTON + DUMP + ADP
BioCyc:DUTP-PYROP-RXN 3.6.1.23 DUTP + WATER --> PROTON + DUMP + PPI
BioCyc:THYMIDYLATESYN-RXN 2.1.1.45 METHYLENE-THF-GLU-N + DUMP --> TMP + DIHYDROFOLATE-GLU-N
BioCyc:RXN-14143 3.1.3.89 DUMP + WATER --> DEOXYURIDINE + Pi
BioCyc:3.5.4.30-RXN 3.5.4.30 DCTP + 2 WATER --> DUMP + PPI + AMMONIUM
BioCyc:RXN-14220 DUDP + WATER<=>DUMP + Pi + PROTON
BioCyc:RXN-14199 3.6.1.5 DUTP + 2 WATER --> DUMP + 2 Pi + 2 PROTON
BioCyc:RXN-14122 2.7.4.13 ATP + DUMP --> ADP + DUDP
BioCyc:DCMP-DEAMINASE-RXN 3.5.4.12 PROTON + DCMP + WATER --> AMMONIUM + DUMP
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
BioCyc:LEISH_PWY3IU-235 folate metabolism
BioCyc:LEISH_PWY0-166 pyrimidine deoxyribonucleotides de novo biosynthesis I
BioCyc:TRYPANO_P1-PWY purine and pyrimidine metabolism
BioCyc:TRYPANO_PWY0-166 pyrimidine deoxyribonucleotides de novo biosynthesis I
BioCyc:TRYPANO_PWY-3841 formylTHF biosynthesis II
BioCyc:CALBI_YEAST-SALV-PYRMID-DNTP salvage pathways of pyrimidine deoxyribonucleotides
BioCyc:CALBI_PWY0-166 pyrimidine deoxyribonucleotides de novo biosynthesis
BioCyc:LEISH_PWY0-181 salvage pathways of pyrimidine deoxyribonucleotides
BioCyc:TRYPANO_PWY0-181 salvage pathways of pyrimidine deoxyribonucleotides
BioCyc:TRYPANO_1CMET2-PWY formylTHF biosynthesis I
BioCyc:CALBI_PWY-3841 folate transformations II
PathBank:SMP0000959 Pyrimidine Metabolism
PathBank:SMP0001750 One Carbon Pool by Folate
PathBank:SMP0002073 Salvage Pathways of Pyrimidine Deoxyribonucleotides
WikiPathways:WP2525 Trans-sulfuration, one-carbon metabolism and related pathways
WikiPathways:WP3604 Biochemical pathways: part I
WikiPathways:WP435 One-carbon metabolism
WikiPathways:WP1026 One-carbon metabolism
WikiPathways:WP3275 Fluoropyrimidine activity
WikiPathways:WP3996 Ethanol effects on histone modifications
View All Pathways