EC: 7.2.2.10

P-type Ca2+ transporter (ATP phosphohydrolase (P-type, Ca2+-transporting))

enzyme lambda metabolic reaction experiment
- [Ca2+-transporting ATPase(Enzyme) wildtype]

Ca2+ + H2O + ATP -> ADP + Phosphate + Ca2+		 (v0 + (( (vmax + v0) ) * (( (X ^ h) ) * (( (( (K_half ^ h) ) + (X ^ h)) ) ^ (0 - 1))))) buffer: 20 mM HEPES, 0.5 mM EGTA, 100 mM KCl, 5.0 mM MgCl2, 4.0 mM NaN3, 1.0 µM A23187, 0.025 mM C12E8
PH: 7.4
Temperature: 25
- [Ca2+-transporting ATPase(Enzyme) wildtype]

H2O + Ca2+ + ATP -> Phosphate + ADP + Ca2+		 (vmax + (( (vinf - vmax) ) * (( (X ^ h) ) * (( (( (I_half ^ h) ) + (X ^ h)) ) ^ (0 - 1))))) buffer: 20 mM HEPES, 0.5 mM EGTA, 100 mM KCl, 5.0 mM MgCl2, 4.0 mM NaN3, 1.0 µM A23187, 0.025 mM C12E8
PH: 7.4
Temperature: 25
- [Ca2+-transporting ATPase(Enzyme) wildtype]

ATP + Ca2+ + H2O -> Phosphate + ADP + Ca2+		 (v0 + (( (vmax + v0) ) * (( (X ^ h) ) * (( (( (K_half ^ h) ) + (X ^ h)) ) ^ (0 - 1))))) buffer: 20 mM HEPES, 0.5 mM EGTA, 100 mM KCl, 5.0 mM MgCl2, 4.0 mM NaN3, 1.0 µM A23187, 0.025 mM C12E8
PH: 7.4
Temperature: 25
- [Ca2+-transporting ATPase(Enzyme) wildtype]

ATP + Ca2+ + H2O -> Phosphate + ADP + Ca2+		 (vmax + (( (vinf - vmax) ) * (( (X ^ h) ) * (( (( (I_half ^ h) ) + (X ^ h)) ) ^ (0 - 1))))) buffer: 20 mM HEPES, 0.5 mM EGTA, 100 mM KCl, 5.0 mM MgCl2, 4.0 mM NaN3, 1.0 µM A23187, 0.025 mM C12E8
PH: 7.4
Temperature: 25
- [Ca2+-transporting ATPase(Enzyme) wildtype]

ATP + H2O + Ca2+ -> ADP + Phosphate + Ca2+		 (v0 + (( (vmax + v0) ) * (( (X ^ h) ) * (( (( (K_half ^ h) ) + (X ^ h)) ) ^ (0 - 1))))) buffer: 20 mM HEPES, 0.5 mM EGTA, 100 mM KCl, 5.0 mM MgCl2, 4.0 mM NaN3, 1.0 µM A23187, 0.025 mM C12E8
PH: 7.4
Temperature: 25
- [Ca2+-transporting ATPase(Enzyme) wildtype]

Ca2+ + ATP + H2O -> ADP + Phosphate + Ca2+		 (vmax + (( (vinf - vmax) ) * (( (X ^ h) ) * (( (( (I_half ^ h) ) + (X ^ h)) ) ^ (0 - 1))))) buffer: 20 mM HEPES, 0.5 mM EGTA, 100 mM KCl, 5.0 mM MgCl2, 4.0 mM NaN3, 1.0 µM A23187, 0.025 mM C12E8
PH: 7.4
Temperature: 25
- [Ca2+-transporting ATPase(Enzyme) wildtype]

H2O + ATP + Ca2+ -> Phosphate + Ca2+ + ADP		 (v0 + (( (vmax + v0) ) * (( (X ^ h) ) * (( (( (K_half ^ h) ) + (X ^ h)) ) ^ (0 - 1))))) buffer: 20 mM HEPES, 0.5 mM EGTA, 100 mM KCl, 5.0 mM MgCl2, 4.0 mM NaN3, 1.0 µM A23187, 0.025 mM C12E8
PH: 7.4
Temperature: 25
- [Ca2+-transporting ATPase(Enzyme) wildtype]

H2O + ATP + Ca2+ -> ADP + Ca2+ + Phosphate		 (vmax + (( (vinf - vmax) ) * (( (X ^ h) ) * (( (( (I_half ^ h) ) + (X ^ h)) ) ^ (0 - 1))))) buffer: 20 mM HEPES, 0.5 mM EGTA, 100 mM KCl, 5.0 mM MgCl2, 4.0 mM NaN3, 1.0 µM A23187, 0.025 mM C12E8
PH: 7.4
Temperature: 25
uniprot:O75185 [Ca2+-transporting ATPase(Enzyme) wildtype SPCA2, C-terminal His10-tagged]

ATP + H2O + Ca2+ -> ADP + Phosphate + Ca2+		 (( (Vmax * (A ^ n)) ) / (( (A_half ^ n) ) + (A ^ n))) buffer: not available
PH: 7
Temperature: 36
uniprot:P98194 [Ca2+-transporting ATPase(Enzyme) wildtype SPCA1a, C-terminal His8-tagged]

Ca2+ + ATP + H2O -> Ca2+ + ADP + Phosphate		 (( (Vmax * (A ^ n)) ) / (( (A_half ^ n) ) + (A ^ n))) buffer: *
PH: 7
Temperature: 36

Pathways

pathway id name
Plant Reactome:R-OSA-9766881 TF network involved in salinity response
Plant Reactome:R-OSA-8932729 Responses to stimuli: abiotic stimuli and stresses
Plant Reactome:R-OSA-9638808 Response to salinity
Reactome:R-HSA-9659379 Sensory processing of sound
Reactome:R-HSA-9709957 Sensory Perception
Reactome:R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea
Reactome:R-BTA-5576891 Cardiac conduction
Reactome:R-DME-418346 Platelet homeostasis
Reactome:R-DME-5576891 Cardiac conduction
Reactome:R-RNO-5578775 Ion homeostasis
Reactome:R-SCE-418346 Platelet homeostasis
Reactome:R-SCE-5576891 Cardiac conduction
Reactome:R-SPO-418359 Reduction of cytosolic Ca++ levels
Reactome:R-SPO-397014 Muscle contraction
Reactome:R-DME-382551 Transport of small molecules
Reactome:R-DME-936837 Ion transport by P-type ATPases
Reactome:R-DME-109582 Hemostasis
Reactome:R-DME-418360 Platelet calcium homeostasis
Reactome:R-DME-5578775 Ion homeostasis
Reactome:R-HSA-5578775 Ion homeostasis
Reactome:R-MMU-5578775 Ion homeostasis
Reactome:R-RNO-397014 Muscle contraction
Reactome:R-SCE-109582 Hemostasis
Reactome:R-SCE-418359 Reduction of cytosolic Ca++ levels
Reactome:R-SCE-382551 Transport of small molecules
Reactome:R-SCE-936837 Ion transport by P-type ATPases
Reactome:R-SCE-397014 Muscle contraction
Reactome:R-SPO-418360 Platelet calcium homeostasis
Reactome:R-BTA-397014 Muscle contraction
Reactome:R-DME-418359 Reduction of cytosolic Ca++ levels
Reactome:R-HSA-5576891 Cardiac conduction
Reactome:R-MMU-5576891 Cardiac conduction
Reactome:R-SCE-5578775 Ion homeostasis
Reactome:R-SPO-382551 Transport of small molecules
Reactome:R-SPO-983712 Ion channel transport
Reactome:R-SPO-109582 Hemostasis
Reactome:R-SPO-5576891 Cardiac conduction
Reactome:R-BTA-5578775 Ion homeostasis
Reactome:R-DME-983712 Ion channel transport
Reactome:R-DME-397014 Muscle contraction
Reactome:R-HSA-397014 Muscle contraction
Reactome:R-MMU-397014 Muscle contraction
Reactome:R-RNO-5576891 Cardiac conduction
Reactome:R-SCE-418360 Platelet calcium homeostasis
Reactome:R-SCE-983712 Ion channel transport
Reactome:R-SPO-936837 Ion transport by P-type ATPases
Reactome:R-SPO-418346 Platelet homeostasis
Reactome:R-SPO-5578775 Ion homeostasis
WikiPathways:WP4838 Regucalcin in proximal tubule epithelial kidney cells
PathBank:SMP0119378 Muscle/Heart Contraction
PathBank:SMP0000296 Acebutolol Action Pathway
PathBank:SMP0000300 Bisoprolol Action Pathway
PathBank:SMP0000304 Oxprenolol Action Pathway
PathBank:SMP0000323 Quinidine Action Pathway
PathBank:SMP0000327 Phenytoin (Antiarrhythmic) Action Pathway
PathBank:SMP0000331 Flecainide Action Pathway
PathBank:SMP0000367 Carvedilol Action Pathway
PathBank:SMP0000377 Felodipine Action Pathway
PathBank:SMP0000381 Nisoldipine Action Pathway
PathBank:SMP0000657 Bopindolol Action Pathway
PathBank:SMP0000661 Epinephrine Action Pathway
PathBank:SMP0000665 Amiodarone Action Pathway
PathBank:SMP0000669 Practolol Action Pathway
PathBank:SMP0000299 Betaxolol Action Pathway
PathBank:SMP0000303 Nadolol Action Pathway
PathBank:SMP0000307 Propranolol Action Pathway
PathBank:SMP0000326 Fosphenytoin (Antiarrhythmic) Action Pathway
PathBank:SMP0000330 Tocainide Action Pathway
PathBank:SMP0000366 Nebivolol Action Pathway
PathBank:SMP0000376 Amlodipine Action Pathway
PathBank:SMP0000380 Nimodipine Action Pathway
PathBank:SMP0000588 Striated Muscle Contraction
PathBank:SMP0000660 Sotalol Action Pathway
PathBank:SMP0000664 Arbutamine Action Pathway
PathBank:SMP0000668 Bevantolol Action Pathway
PathBank:SMP0000297 Alprenolol Action Pathway
PathBank:SMP0000301 Esmolol Action Pathway
PathBank:SMP0000305 Penbutolol Action Pathway
PathBank:SMP0000324 Procainamide (Antiarrhythmic) Action Pathway
PathBank:SMP0000328 Lidocaine (Antiarrhythmic) Action Pathway
PathBank:SMP0000332 Ibutilide Action Pathway
PathBank:SMP0000368 Labetalol Action Pathway
PathBank:SMP0000378 Isradipine Action Pathway
PathBank:SMP0000382 Nitrendipine Action Pathway
PathBank:SMP0000658 Carteolol Action Pathway
PathBank:SMP0000662 Dobutamine Action Pathway
PathBank:SMP0000666 Levobunolol Action Pathway
PathBank:SMP0000670 Bupranolol Action Pathway
PathBank:SMP0000298 Atenolol Action Pathway
PathBank:SMP0000302 Metoprolol Action Pathway
PathBank:SMP0000306 Pindolol Action Pathway
PathBank:SMP0000325 Disopyramide Action Pathway
PathBank:SMP0000329 Mexiletine Action Pathway
PathBank:SMP0000359 Diltiazem Action Pathway
PathBank:SMP0000375 Verapamil Action Pathway
PathBank:SMP0000379 Nifedipine Action Pathway
PathBank:SMP0000659 Timolol Action Pathway
PathBank:SMP0000663 Isoprenaline Action Pathway
PathBank:SMP0000667 Metipranolol Action Pathway