moxF - Methylobacterium organophilum

Methanol dehydrogenase [cytochrome c] subunit 1

Calcium Cell inner membrane Cell membrane Direct protein sequencing Disulfide bond Membrane Metal-binding Methanol utilization Oxidoreductase PQQ Signal

Cell inner membrane
> moxF - Methylobacterium organophilum [Methanol dehydrogenase [cytochrome c] subunit 1]
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统计信息
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Metadata

Organism Source: 410 - Methylobacterium organophilum
EC Number: 1.1.2.7
Cluster:
Registry Model:

Reactions

reaction id name note
KEGG:R01146 methanol:ferricytochrome-c oxidoreductase; Methanol + 2 Ferricytochrome cL <=> Formaldehyde + 2 Ferrocytochrome cL + 2 H+
KEGG:R09127 ethanol:cytochrome c oxidoreductase Ethanol + 2 Ferricytochrome cL <=> Acetaldehyde + 2 Ferrocytochrome cL + 2 H+
KEGG:R09128 2-chloroethanol:cytochrome c oxidoreductase 2-Chloroethanol + 2 Ferricytochrome cL <=> Chloroacetaldehyde + 2 Ferrocytochrome cL + 2 H+
KEGG:R10713 primary alcohol:cytochrome cL oxidoreductase Primary alcohol + 2 Ferricytochrome cL <=> Aldehyde + 2 Ferrocytochrome cL + 2 H+
Rhea:RHEA:51005 2 Fe(III)-[cytochrome cL] + a primary alcohol => 2 Fe(II)-[cytochrome cL] + an aldehyde + 2 H+
Rhea:RHEA:51006 2 Fe(II)-[cytochrome cL] + an aldehyde + 2 H+ => 2 Fe(III)-[cytochrome cL] + a primary alcohol
Rhea:RHEA:51007 2 Fe(III)-[cytochrome cL] + a primary alcohol <=> 2 Fe(II)-[cytochrome cL] + an aldehyde + 2 H+
Rhea:RHEA:51009 2 Fe(III)-[cytochrome cL] + methanol => 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H+
Rhea:RHEA:51010 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H+ => 2 Fe(III)-[cytochrome cL] + methanol
Rhea:RHEA:51011 2 Fe(III)-[cytochrome cL] + methanol <=> 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H+
BioCyc:RXN-11332 Primary-Alcohols + 2 Cytochromes-CL-Ox<=>Aldehydes + 2 Cytochromes-CL-Red + 2 PROTON
BioCyc:RXN-2861 METOH + 2 Cytochromes-CL-Ox --> FORMALDEHYDE + 2 Cytochromes-CL-Red + 2 PROTON A periplasmic quinoprotein alcohol dehydrogenase that only occurs in methylotrophic bacteria. It uses the novel specific cytochrome cL as acceptor. Acts on a wide range of primary alcohols, including ethanol, duodecanol, chloroethanol, cinnamyl alcohol, and also formaldehyde. Activity is stimulated by ammonia or methylamine. It is usually assayed with phenazine methosulphate. Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed �propeller� structure, a calcium ion bound to the PQQ in the active site and an unusual disulphide ring structure in close proximity to the PQQ. It differs from |FRAME: RXN-11333 "EC 1.1.2.8, alcohol dehydrogenase (cytochrome c)"|, in having a high affinity for methanol and in having a second essential small subunit (no known function).
BioCyc:MOXXANAU-RXN 2-CHLOROETHANOL + 2 Cytochromes-CL-Ox<=>CHLOROACETALDEHYDE + 2 Cytochromes-CL-Red + 2 PROTON

Pathways

pathway id name
BioCyc:META_PWY-6966 methanol oxidation to formaldehyde I
BioCyc:META_PWY-1701 methanol and methylamine oxidation to formaldehyde
BioCyc:META_PWY-1882 superpathway of C1 compounds oxidation to CO2