sphingosine and sphingosine-1-phosphate metabolism

Le Stunff H, Milstien S, Spiegel S. Generation and metabolism of bioactive sphingosine-1-phosphate. J Cell Biochem. 2004 Aug 01;92(5):882–99. doi: 10.1002/jcb.20097. PMID: 15258913.; Cuvillier O. Sphingosine in apoptosis signaling. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2002 Dec;1585(2-3):153–62. doi: 10.1016/s1388-1981(02)00336-0.

Metabolites

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hexadecanal

Formula: C16H32O (240.2453022)

CAS ID: 629-80-1

Hexadecenal

Formula: C16H30O (238.22965299999998)

CAS ID: 3163-37-9

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
2.3.1.-
1.3.1.48 13,14-dehydro-15-oxoprostaglandin 13-reductase 11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase
1.3.1.74 2-alkenal reductase [NAD(P)+] n-alkanal:NAD(P)+ 2-oxidoreductase
2.7.1.91 sphingosine kinase ATP:sphingoid base 1-phosphotransferase
3.5.1.23 ceramidase N-acylsphingosine amidohydrolase
4.1.2.27 sphinganine-1-phosphate aldolase sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)


Proteins

Protein ID name full name