farnesylcysteine salvage pathway

Huizinga DH, Denton R, Koehler KG, Tomasello A, Wood L, Sen SE, Crowell DN. Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis. Mol Plant. 2010 Jan;3(1):143–55. PMID: 19969520; PMCID: PMC2807925.; Crowell DN, Huizinga DH, Deem AK, Trobaugh C, Denton R, Sen SE. Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine. The Plant Journal. 2007 Apr 08;50(5):839–47. doi: 10.1111/j.1365-313x.2007.03091.x.; Thai L, Rush JS, Maul JE, Devarenne T, Rodgers DL, Chappell J, Waechter CJ. Farnesol is utilized for isoprenoid biosynthesis in plant cells via farnesyl pyrophosphate formed by successive monophosphorylation reactions. Proc. Natl. Acad. Sci. U.S.A. 1999 Nov 09;96(23):13080–5. doi: 10.1073/pnas.96.23.13080.; Bentinger M, Grünler J, Peterson E, Swiezewska E, Dallner G. Phosphorylation of Farnesol in Rat Liver Microsomes: Properties of Farnesol Kinase and Farnesyl Phosphate Kinase. Archives of Biochemistry and Biophysics. 1998 May;353(2):191–8. doi: 10.1006/abbi.1998.0611.; Crick DC, Andres DA, Waechter CJ. Novel Salvage Pathway Utilizing Farnesol and Geranylgeraniol for Protein Isoprenylation. Biochemical and Biophysical Research Communications. 1997 Aug;237(3):483–7. doi: 10.1006/bbrc.1997.7145.; Zhang FL, Casey PJ. Protein prenylation: molecular mechanisms and functional consequences. Annu Rev Biochem. 1996;65():241–69. doi: 10.1146/annurev.bi.65.070196.001325. PMID: 8811180.

Metabolites

(2E,6E)-Farnesol

Formula: C15H26O (222.1983546)

CAS ID: 106-28-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.8.3.6 farnesylcysteine lyase S-(2E,6E)-farnesyl-L-cysteine oxidase
2.7.1.216 farnesol kinase CTP:(2E,6E)-farnesol phosphotransferase


Proteins

Protein ID name full name