siroheme biosynthesis

Warren MJ, Bolt EL, Roessner CA, Scott AI, Spencer JB, Woodcock SC. Gene dissection demonstrates that the Escherichia coli cysG gene encodes a multifunctional protein. Biochem J. 1994 Sep 15;302 ( Pt 3)():837–44. PMID: 7945210; PMCID: PMC1137306.

Metabolites

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

siroheme(8-)

Formula: C42H36FeN4O16 (908.1475605999999)

CAS ID: 52553-42-1

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
1.3.1.76 precorrin-2 dehydrogenase precorrin-2:NAD+ oxidoreductase
2.1.1.107 uroporphyrinogen-III C-methyltransferase S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase
4.99.1.4 sirohydrochlorin ferrochelatase siroheme ferro-lyase (sirohydrochlorin-forming)


Proteins

Protein ID name full name
P0AEA8 cysG Siroheme synthase