thyroid hormone biosynthesis

Bizhanova A, Kopp P: Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. Endocrinology. 2009 Mar;150(3):1084-90. doi: 10.1210/en.2008-1437. Epub 2009 Feb 5.; Ruf J, Carayon P. Structural and functional aspects of thyroid peroxidase. Archives of Biochemistry and Biophysics. 2006 Jan;445(2):269–77. doi: 10.1016/j.abb.2005.06.023.; Friedrichs B, Tepel C, Reinheckel T, Deussing J, von Figura K, Herzog V, Peters C, Saftig P, Brix K. Thyroid functions of mouse cathepsins B, K, and L. J Clin Invest. 2003 Jun;111(11):1733–45. PMID: 12782676; PMCID: PMC156100.; Dunn JT, Dunn AD. Update on intrathyroidal iodine metabolism. Thyroid. 2001 May;11(5):407–14. doi: 10.1089/105072501300176363. PMID: 11396699.; Dunn JT, Dunn AD. The importance of thyroglobulin structure for thyroid hormone biosynthesis**We shared with our friend and colleague, the late Gaetano Salvatore, a long–standing interest in thyroglobulin structure, as well as a broader interest in the optimal production of thyroid hormone and its dependence on adequate iodine supply. Over the years, we frequently discussed progress in this field with him and his many co–workers. We now welcome the opportunity to review some of our investigative work in one of his favorite fields, in his honor. Biochimie. 1999 May;81(5):505–9. doi: 10.1016/s0300-9084(99)80102-3.

Metabolites

Amitrole

Formula: C2H4N4 (84.0435944)

CAS ID: 61-82-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen cyanide

Formula: CHN (27.010898599999997)

CAS ID: 74-90-8

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Iodide

Formula: I (126.904477)

CAS ID: 20461-54-5

N-Ethylmaleimide

Formula: C6H7NO2 (125.0476762)

CAS ID: 128-53-0

Pepstatin

Formula: C34H63N5O9 (685.4625548)

CAS ID: 26305-03-3

Phloroglucinol

Formula: C6H6O3 (126.0316926)

CAS ID: 108-73-6

Resorcinol

Formula: C6H6O2 (110.0367776)

CAS ID: 108-46-3

Sulfathiazole

Formula: C9H9N3O2S2 (255.01361740000002)

CAS ID: 72-14-0

Thiamazole

Formula: C4H6N2S (114.02516759999999)

CAS ID: 60-56-0

Thiourea

Formula: CH4N2S (76.0095184)

CAS ID: 62-56-6

Thiocyanate

Formula: CNS (57.975145999999995)

CAS ID: 302-04-5

Hydrazoic acid

Formula: HN3 (43.0170466)

CAS ID: 7782-79-8

4-aminobenzoate

Formula: C7H6NO2 (136.0398516)

CAS ID: 2906-28-7



Enzyme

EC Number name full name note
1.11.1.8 iodide peroxidase iodide:hydrogen-peroxide oxidoreductase
3.4.22.1 cathepsin B
3.4.22.15 cathepsin L
3.4.22.38 cathepsin K
3.4.23.5 cathepsin D


Proteins

Protein ID name full name