thyroid hormone metabolism I (via deiodination)

St Germain DL, Galton VA, Hernandez A. Minireview: Defining the roles of the iodothyronine deiodinases: current concepts and challenges. Endocrinology. 2009 Mar;150(3):1097–107. PMID: 19179439; PMCID: PMC2654746.; Moreno M, de Lange P, Lombardi A, Silvestri E, Lanni A, Goglia F. Metabolic effects of thyroid hormone derivatives. Thyroid. 2008 Feb;18(2):239–53. doi: 10.1089/thy.2007.0248. PMID: 18279024.; Wu SY, Green WL, Huang WS, Hays MT, Chopra IJ. Alternate pathways of thyroid hormone metabolism. Thyroid. 2005 Aug;15(8):943–58. doi: 10.1089/thy.2005.15.943. PMID: 16131336.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Iodide

Formula: I (126.904477)

CAS ID: 20461-54-5

selenide

Formula: Se (79.916521)

CAS ID: 22541-48-6



Enzyme

EC Number name full name note
1.21.99.3 thyroxine 5-deiodinase 3,3',5'-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
1.21.99.4 thyroxine 5'-deiodinase 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)


Proteins

Protein ID name full name