methyl tert-butyl ether degradation

Hyman M. Biodegradation of gasoline ether oxygenates. Curr Opin Biotechnol. 2013 Jun;24(3):443–50. doi: 10.1016/j.copbio.2012.10.005. PMID: 23116604.; Yaneva N, Schuster J, Schäfer F, Lede V, Przybylski D, Paproth T, Harms H, Müller RH, Rohwerder T. Bacterial Acyl-CoA Mutase Specifically Catalyzes Coenzyme B12-dependent Isomerization of 2-Hydroxyisobutyryl-CoA and (S)-3-Hydroxybutyryl-CoA. Journal of Biological Chemistry. 2012 May;287(19):15502–11. doi: 10.1074/jbc.m111.314690.; Hristova KR, Schmidt R, Chakicherla AY, Legler TC, Wu J, Chain PS, Scow KM, Kane SR. Comparative Transcriptome Analysis of Methylibium petroleiphilum PM1 Exposed to the Fuel Oxygenates Methyl tert -Butyl Ether and Ethanol. Appl Environ Microbiol. 2007 Nov 15;73(22):7347–57. doi: 10.1128/aem.01604-07.; Smith CA, O'Reilly KT, Hyman MR. Characterization of the Initial Reactions during the Cometabolic Oxidation of Methyl tert -Butyl Ether by Propane-Grown Mycobacterium vaccae JOB5. Appl Environ Microbiol. 2003 Feb;69(2):796–804. doi: 10.1128/aem.69.2.796-804.2003.

Metabolites

2-Hydroxy-2-methylpropanal

Formula: C4H8O2 (88.0524268)

CAS ID: 20818-81-9

2-Methylpropane-1,2-diol

Formula: C4H10O2 (90.068076)

CAS ID: 558-43-0

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Methyl tert-butyl ether

Formula: C5H12O (88.0888102)

CAS ID: 1634-04-4

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

tert-Butyl alcohol

Formula: C4H10O (74.073161)

CAS ID: 75-65-0

Tert-butyl formate

Formula: C5H10O2 (102.068076)

CAS ID: 762-75-4

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.400 2-methyl-1,2-propanediol dehydrogenase 2-methylpropane-1,2-diol:NAD+ 1-oxidoreductase
1.2.1.98 2-hydroxy-2-methylpropanal dehydrogenase 2-hydroxy-2-methylpropanal:NAD+ oxidoreductase
5.4.99.64 2-hydroxyisobutanoyl-CoA mutase 2-hydroxy-2-methylpropanoyl-CoA mutase


Proteins

Protein ID name full name
I3VE74 hcmB 2-hydroxyisobutanoyl-CoA mutase small subunit
I3VE77 hcmA 2-hydroxyisobutanoyl-CoA mutase large subunit
Q3YAT3 mpdB 2-methyl-1,2-propanediol dehydrogenase
Q3YAT5 mpdC Hydroxyisobutyraldehyde dehydrogenase