lipoate biosynthesis and incorporation II

Zhao X, Miller JR, Jiang Y, Marletta MA, Cronan JE. Assembly of the covalent linkage between lipoic acid and its cognate enzymes. Chem Biol. 2003 Dec;10(12):1293–302. doi: 10.1016/j.chembiol.2003.11.016. PMID: 14700636.

Metabolites

5'-Deoxyadenosine

Formula: C10H13N5O3 (251.10183480000003)

CAS ID: 4754-39-6

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Sulfur

Formula: S (31.972072)

CAS ID: 7704-34-9

octanoate

Formula: C8H15O2 (143.107199)

CAS ID: 74-81-7

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:



Enzyme

EC Number name full name note
2.8.1.8 lipoyl synthase [protein]-N6-(octanoyl)-L-lysine:an [Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster sulfurtransferase
6.3.1.20 lipoate-protein ligase [lipoyl-carrier protein]-L-lysine:lipoate ligase (AMP-forming)


Proteins

Protein ID name full name
P32099 lplA Lipoate-protein ligase A
P60716 lipA Lipoyl synthase