6-hydroxymethyl-dihydropterin diphosphate biosynthesis I

Basset G, Quinlivan EP, Ziemak MJ, Diaz De La Garza R, Fischer M, Schiffmann S, Bacher A, Gregory JF, Hanson AD. Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12489–94. PMID: 12221287; PMCID: PMC129472.

Metabolites

6-(Hydroxymethyl)-7,8-dihydropterin

Formula: C7H9N5O2 (195.07562140000002)

CAS ID: 3672-03-5

6-Hydroxymethyl-7,8-dihydropterin diphosphate

Formula: C7H11N5O8P2 (355.00828659999996)

CAS ID: 3545-84-4

Formate

Formula: CH2O2 (46.0054792)

CAS ID: 64-18-6

Glycolaldehyde

Formula: C2H4O2 (60.0211284)

CAS ID: 141-46-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:



Enzyme

EC Number name full name note
2.5.1.15 dihydropteroate synthase (7,8-dihydropterin-6-yl)methyl diphosphate:4-aminobenzoate 2-amino-4-hydroxy-7,8-dihydropteridine-6-methenyltransferase
2.7.6.3 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase ATP:6-hydroxymethyl-7,8-dihydropterin 6'-diphosphotransferase
3.5.4.16 GTP cyclohydrolase I GTP 7,8-8,9-dihydrolase
3.6.1.22 NAD+ diphosphatase NAD+ phosphohydrolase
3.6.1.55 8-oxo-dGTP diphosphatase 8-oxo-dGTP diphosphohydrolase
3.6.1.67 dihydroneopterin triphosphate diphosphatase 7,8-dihydroneopterin 3'-triphosphate diphosphohydrolase
4.1.2.25 dihydroneopterin aldolase 7,8-dihydroneopterin glycolaldehyde-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]


Proteins

Protein ID name full name