glycocholate metabolism (bacteria)

Ridlon JM, Kang DJ, Hylemon PB: Bile salt biotransformations by human intestinal bacteria. J Lipid Res. 2006 Feb;47(2):241-59. doi: 10.1194/jlr.R500013-JLR200. Epub 2005 Nov 18.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Copper

Formula: Cu (62.929599)

CAS ID: 7440-50-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Mercury(2+)

Formula: Hg (201.970632)

CAS ID: 14302-87-5

N-Ethylmaleimide

Formula: C6H7NO2 (125.0476762)

CAS ID: 128-53-0

Silver

Formula: Ag (106.905095)

CAS ID: 7440-22-4

cholate

Formula: C24H39O5 (407.2797344)

CAS ID: 298-43-1

3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate

Formula: C24H37O5 (405.2640852)

CAS ID:

3alpha,7alpha,12beta-trihydroxy-5beta-cholanate

Formula: C24H39O5 (407.2797344)

CAS ID:

3beta,7alpha,12alpha-trihydroxy-5beta-cholan-24-oate

Formula: C24H39O5 (407.2797344)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

pyridoxal 5'-phosphate(2-)

Formula: C8H8NO6P (245.0089238)

CAS ID:

p-hydroxymercuribenzoic acid

Formula: C7H6HgO3 (340.00232459999995)

CAS ID: 1126-48-3



Enzyme

EC Number name full name note
2.3.1.-
1.1.1.176 12alpha-hydroxysteroid dehydrogenase 12alpha-hydroxysteroid:NADP+ 12-oxidoreductase
3.5.1.24 choloylglycine hydrolase 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase
3.5.1.74 chenodeoxycholoyltaurine hydrolase chenodeoxycholoyltaurine amidohydrolase


Proteins

Protein ID name full name
P21215 12AH_CLOS4 12-alpha-hydroxysteroid dehydrogenase
P54965 cbh Bile salt hydrolase/transferase
Q9KK62 bsh Bile salt hydrolase/transferase