catechol degradation II (meta-cleavage pathway)

Marín M, Plumeier I, Pieper DH. Degradation of 2,3-dihydroxybenzoate by a novel meta-cleavage pathway. J Bacteriol. 2012 Aug;194(15):3851–60. PMID: 22609919; PMCID: PMC3416551.; Sala-Trepat JM, Evans WC. The meta cleavage of catechol by Azotobacter species. 4-Oxalocrotonate pathway. Eur J Biochem. 1971 Jun 11;20(3):400–13. doi: 10.1111/j.1432-1033.1971.tb01406.x. PMID: 4325686.

Metabolites

Acetaldehyde

Formula: C2H4O (44.0262134)

CAS ID: 75-07-0

Catechol

Formula: C6H6O2 (110.0367776)

CAS ID: 120-80-9

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
4.2.-.-
1.13.11.2 catechol 2,3-dioxygenase catechol:oxygen 2,3-oxidoreductase (decyclizing)
1.2.1.10 acetaldehyde dehydrogenase (acetylating) acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)
1.2.1.85 2-hydroxymuconate-6-semialdehyde dehydrogenase 2-hydroxymuconate-6-semialdehyde:NAD+ oxidoreductase
4.1.1.77 2-oxo-3-hexenedioate decarboxylase (3E)-2-oxohex-3-enedioate carboxy-lyase (2-oxopent-4-enoate-forming)
4.1.3.39 4-hydroxy-2-oxovalerate aldolase 4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)
5.3.2.6 2-hydroxymuconate tautomerase (2Z,4E)-2-hydroxyhexa-2,4-dienedioate keto-enol isomerase


Proteins

Protein ID name full name
P06622 xylE Metapyrocatechase
P23105 xylG 2-hydroxymuconic semialdehyde dehydrogenase
P23107 xylJ 2-hydroxypent-2,4-dienoate hydratase
P49155 xylI 4-oxalocrotonate decarboxylase
P51016 dmpG 4-hydroxy-2-oxovalerate aldolase
P51019 xylK 4-hydroxy-2-oxovalerate aldolase
Q01468 xylH 2-hydroxymuconate tautomerase
Q52060 dmpF Acetaldehyde dehydrogenase