urate conversion to allantoin II

Michiel M, Perchat N, Perret A, Tricot S, Papeil A, Besnard M, de Berardinis V, Salanoubat M, Fischer C. Microbial urate catabolism: characterization of HpyO , a non-homologous isofunctional isoform of the flavoprotein urate hydroxylase HpxO. Environ Microbiol Rep. 2012 Sep 25;4(6):642–7. doi: 10.1111/j.1758-2229.2012.00390.x.; O’Leary SE, Hicks KA, Ealick SE, Begley TP. Biochemical Characterization of the HpxO Enzyme from Klebsiella pneumoniae, a Novel FAD-Dependent Urate Oxidase. Biochemistry. 2009 Mar 20;48(14):3033–5. doi: 10.1021/bi900160b.

Metabolites

(S)-Allantoin

Formula: C4H6N4O3 (158.0439886)

CAS ID: 3844-67-5

5-Hydroxyisourate

Formula: C5H4N4O4 (184.02325439999998)

CAS ID: 151359-24-9

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Allopurinol

Formula: C5H4N4O (136.03850939999998)

CAS ID: 315-30-0

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
1.14.13.-
1.14.13.113 FAD-dependent urate hydroxylase urate,NADH:oxygen oxidoreductase (5-hydroxyisourate-forming)


Proteins

Protein ID name full name
B6D1N4 hpxO FAD-dependent urate hydroxylase
Q8PDQ6 XCC0279 monoxygenase