heme b biosynthesis I (aerobic)

Nagai S, Koide M, Takahashi S, Kikuta A, Aono M, Sasaki-Sekimoto Y, Ohta H, Takamiya K, Masuda T. Induction of isoforms of tetrapyrrole biosynthetic enzymes, AtHEMA2 and AtFC1, under stress conditions and their physiological functions in Arabidopsis. Plant Physiol. 2007 Jun;144(2):1039–51. PMID: 17416636; PMCID: PMC1914178.; Oborník M, Green BR. Mosaic origin of the heme biosynthesis pathway in photosynthetic eukaryotes. Mol Biol Evol. 2005 Dec;22(12):2343–53. doi: 10.1093/molbev/msi230. PMID: 16093570.; Frankenberg N, Moser J, Jahn D. Bacterial heme biosynthesis and its biotechnological application. Applied Microbiology and Biotechnology. 2003 Dec 01;63(2):115–27. doi: 10.1007/s00253-003-1432-2.; Panek H, O'Brian MR. A whole genome view of prokaryotic haem biosynthesis. Microbiology (Reading). 2002 Aug;148(Pt 8):2273–82. doi: 10.1099/00221287-148-8-2273. PMID: 12177321.; Leustek T, Smith M, Murillo M, Singh DP, Smith AG, Woodcock SC, Awan SJ, Warren MJ. Siroheme biosynthesis in higher plants. Analysis of an S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase from Arabidopsis thaliana. J Biol Chem. 1997 Jan 31;272(5):2744–52. doi: 10.1074/jbc.272.5.2744. PMID: 9006913.; Narita S, Tanaka R, Ito T, Okada K, Taketani S, Inokuchi H. Molecular cloning and characterization of a cDNA that encodes protoporphyrinogen oxidase of Arabidopsis thaliana. Gene. 1996 Dec 05;182(1-2):169–75. doi: 10.1016/s0378-1119(96)00545-8. PMID: 8982084.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7



Enzyme

EC Number name full name note
1.3.3.3 coproporphyrinogen oxidase coproporphyrinogen:oxygen oxidoreductase (decarboxylating)
1.3.3.4 protoporphyrinogen oxidase protoporphyrinogen-IX:oxygen oxidoreductase
4.1.1.37 uroporphyrinogen decarboxylase uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)
4.98.1.1 protoporphyrin ferrochelatase protoheme ferro-lyase (protoporphyrin-forming)


Proteins

Protein ID name full name