molybdenum cofactor biosynthesis

Zhang W, Urban A, Mihara H, Leimkühler S, Kurihara T, Esaki N. IscS Functions as a Primary Sulfur-donating Enzyme by Interacting Specifically with MoeB and MoaD in the Biosynthesis of Molybdopterin in Escherichia coli. Journal of Biological Chemistry. 2010 Jan;285(4):2302–8. doi: 10.1074/jbc.m109.082172.; Schwarz G, Mendel RR. Molybdenum cofactor biosynthesis and molybdenum enzymes. Annu Rev Plant Biol. 2006;57():623–47. doi: 10.1146/annurev.arplant.57.032905.105437. PMID: 16669776.; Frazzon J, Dean DR. Formation of iron-sulfur clusters in bacteria: an emerging field in bioinorganic chemistry. Curr Opin Chem Biol. 2003 Apr;7(2):166–73. doi: 10.1016/s1367-5931(03)00021-8. PMID: 12714048.; Gutzke G, Fischer B, Mendel RR, Schwarz G. Thiocarboxylation of Molybdopterin Synthase Provides Evidence for the Mechanism of Dithiolene Formation in Metal-binding Pterins. Journal of Biological Chemistry. 2001 Sep;276(39):36268–74. doi: 10.1074/jbc.m105321200.; Pitterle DM, Rajagopalan KV. The biosynthesis of molybdopterin in Escherichia coli. Purification and characterization of the converting factor. Journal of Biological Chemistry. 1993 Jun;268(18):13499–505. doi: 10.1016/s0021-9258(19)38677-6.

Metabolites

5'-Deoxyadenosine

Formula: C10H13N5O3 (251.10183480000003)

CAS ID: 4754-39-6

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

molybdate

Formula: MoO4 (161.885065)

CAS ID: 14259-85-9

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2



Enzyme

EC Number name full name note
2.8.1.12 molybdopterin synthase thiocarboxylated molybdopterin synthase:cyclic pyranopterin monophosphate sulfurtransferase
4.1.99.22 GTP 3',8-cyclase GTP 3',8-cyclase [(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate-forming]
4.6.1.17 cyclic pyranopterin monophosphate synthase (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate lyase (cyclic pyranopterin phosphate-forming)


Proteins

Protein ID name full name