GDP-L-fucose biosynthesis I (from GDP-D-mannose)

Nakayama K, Maeda Y, Jigami Y. Interaction of GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase with GDP-mannose-4,6-dehydratase stabilizes the enzyme activity for formation of GDP-fucose from GDP-mannose. Glycobiology. 2003 Oct;13(10):673–80. doi: 10.1093/glycob/cwg099. PMID: 12881408.; Ponce G, Luján R, Campos ME, Reyes A, Nieto-Sotelo J, Feldman LJ, Cassab GI. Three maize root-specific genes are not correctly expressed in regenerated caps in the absence of the quiescent center. Planta. 2000 Jun;211(1):23–33. doi: 10.1007/s004250000276. PMID: 10923700.; Rougier M. Ultrastructural detection of fucosyl residues at the surface of axenically grown maize roots/sequential use of UeA lectin and fucosyl ferritin as the specific glycosylated marker. Eur J Cell Biol. 1984 May;34(1):45–51. PMID: 6734630.; James DW, Jones RL. Characterization of GDP-Fucose: Polysaccharide Fucosyl Transferase in Corn Roots (Zea mays L.). Plant Physiol. 1979 Dec;64(6):909–13. PMID: 16661104; PMCID: PMC543163.; Harris PJ, Northcote DH. Patterns of polysaccharide biosynthesis in differentiating cells of maize root-tips. Biochem J. 1970 Dec;120(3):479–91. PMID: 5499960; PMCID: PMC1179627.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
4.2.1.47 GDP-mannose 4,6-dehydratase GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)


Proteins

Protein ID name full name