D-galacturonate degradation III

Richard P, Hilditch S. d-Galacturonic acid catabolism in microorganisms and its biotechnological relevance. Applied Microbiology and Biotechnology. 2009 Jan 22;82(4):597–604. doi: 10.1007/s00253-009-1870-6.; Martens-Uzunova ES, Schaap PJ. An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation. Fungal Genet Biol. 2008 Nov;45(11):1449–57. doi: 10.1016/j.fgb.2008.08.002. PMID: 18768163.; ISHIKAWA T, MASUMOTO I, IWASA N, NISHIKAWA H, SAWA Y, SHIBATA H, NAKAMURA A, YABUTA Y, SHIGEOKA S. Functional Characterization ofD-Galacturonic Acid Reductase, a Key Enzyme of the Ascorbate Biosynthesis Pathway, fromEuglena gracilis. Bioscience, Biotechnology, and Biochemistry. 2006 Nov 23;70(11):2720–6. doi: 10.1271/bbb.60327.; Agius F, González-Lamothe R, Caballero JL, Muñoz-Blanco J, Botella MA, Valpuesta V. Engineering increased vitamin C levels in plants by overexpression of a D-galacturonic acid reductase. Nat Biotechnol. 2003 Feb;21(2):177–81. doi: 10.1038/nbt777. PMID: 12524550.

Metabolites

D-Galacturonate

Formula: C6H10O7 (194.042651)

CAS ID: 685-73-4

Glycerol

Formula: C3H8O3 (92.0473418)

CAS ID: 56-81-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.365 D-galacturonate reductase L-galactonate:NADP+ oxidoreductase
1.1.1.372 D/L-glyceraldehyde reductase glycerol:NADP+ oxidoreductase (D/L-glyceraldehyde-forming)
4.1.2.54 L-threo-3-deoxy-hexylosonate aldolase 2-dehydro-3-deoxy-L-galactonate L-glyceraldehyde-lyase (pyruvate-forming)
4.2.1.146 L-galactonate dehydratase L-galactonate hydro-lyase (2-dehydro-3-deoxy-L-galactonate-forming)


Proteins

Protein ID name full name
A6Y9S5 lga1 L-threo-3-deoxy-hexylosonate aldolase
Q0GYU5 gld1 D/L-glyceraldehyde reductase
Q0QWS4 lgd1 L-galactonate dehydratase
Q3ZFI7 gar1 D-galacturonate reductase