flavin biosynthesis II (archaea)

Mashhadi Z, Zhang H, Xu H, White RH. Identification and characterization of an archaeon-specific riboflavin kinase. J Bacteriol. 2008 Apr;190(7):2615–8. PMID: 18245297; PMCID: PMC2293203.; Chatwell L, Krojer T, Fidler A, Römisch W, Eisenreich W, Bacher A, Huber R, Fischer M. Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii. J Mol Biol. 2006 Jun 23;359(5):1334–51. doi: 10.1016/j.jmb.2006.04.045. PMID: 16730025.; Graupner M, Xu H, White RH. The Pyrimidine Nucleotide Reductase Step in Riboflavin and F 420 Biosynthesis in Archaea Proceeds by the Eukaryotic Route to Riboflavin. J Bacteriol. 2002 Apr;184(7):1952–7. doi: 10.1128/jb.184.7.1952-1957.2002.

Metabolites

5-Amino-6-(1-D-ribitylamino)uracil

Formula: C9H16N4O6 (276.10697960000005)

CAS ID: 17014-74-3

Cobalt ion

Formula: Co (58.933198)

CAS ID: 22541-53-3

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Lithium

Formula: Li (7.016005)

CAS ID: 7439-93-2

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
1.1.1.302 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one:NAD(P)+ oxidoreductase
2.5.1.78 6,7-dimethyl-8-ribityllumazine synthase 5-amino-6-(D-ribitylamino)uracil butanedionetransferase
2.5.1.9 riboflavin synthase 6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase
2.7.1.161 CTP-dependent riboflavin kinase CTP:riboflavin 5′-phosphotransferase
2.7.7.2 FAD synthase ATP:FMN adenylyltransferase
3.5.1.102 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one amidohydrolase
3.5.4.29 GTP cyclohydrolase IIa GTP 8,9-hydrolase (phosphate-forming)
4.1.99.12 3,4-dihydroxy-2-butanone-4-phosphate synthase D-ribulose 5-phosphate formate-lyase (L-3,4-dihydroxybutan-2-one 4-phosphate-forming)


Proteins

Protein ID name full name
Q57580 arfB 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase
Q57609 gch3 GTP cyclohydrolase III
Q57751 ribH 6,7-dimethyl-8-ribityllumazine synthase
Q58085 arfC 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
Q58579 ribL FAD synthase
Q58584 ribC Riboflavin synthase
Q60364 ribB 3,4-dihydroxy-2-butanone 4-phosphate synthase
Q60365 ribK Riboflavin kinase