benzoyl-CoA degradation I (aerobic)

Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G. Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14390–5. PMID: 20660314; PMCID: PMC2922514.; Gescher J, Ismail W, O¨lgeschla¨ger E, Eisenreich W, Wo¨rth J, Fuchs G. Aerobic Benzoyl-Coenzyme A (CoA) Catabolic Pathway in Azoarcus evansii : Conversion of Ring Cleavage Product by 3,4-Dehydroadipyl-CoA Semialdehyde Dehydrogenase. J Bacteriol. 2006 Apr 15;188(8):2919–27. doi: 10.1128/jb.188.8.2919-2927.2006.; Gescher J, Zaar A, Mohamed M, Scha¨gger H, Fuchs G. Genes Coding for a New Pathway of Aerobic Benzoate Metabolism in Azoarcus evansii. J Bacteriol. 2002 Nov 15;184(22):6301–15. doi: 10.1128/jb.184.22.6301-6315.2002.; Zaar A, Eisenreich W, Bacher A, Fuchs G. A Novel Pathway of Aerobic Benzoate Catabolism in the BacteriaAzoarcus evansii and Bacillus stearothermophilus. Journal of Biological Chemistry. 2001 Jan;276(27):24997–5004. doi: 10.1074/jbc.m100291200.; Mohamed ME, Zaar A, Ebenau-Jehle C, Fuchs G. Reinvestigation of a New Type of Aerobic Benzoate Metabolism in the Proteobacterium Azoarcus evansii. J Bacteriol. 2001 Mar 15;183(6):1899–908. doi: 10.1128/jb.183.6.1899-1908.2001.; Altenschmidt U, Oswald B, Steiner E, Herrmann H, Fuchs G. New aerobic benzoate oxidation pathway via benzoyl-coenzyme A and 3-hydroxybenzoyl-coenzyme A in a denitrifying Pseudomonas sp. J Bacteriol. 1993 Aug;175(15):4851–8. doi: 10.1128/jb.175.15.4851-4858.1993.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.14.13.208 benzoyl-CoA 2,3-epoxidase benzoyl-CoA,NADPH:oxygen oxidoreductase (2,3-epoxydizing)
1.2.1.77 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+) 3,4-dehydroadipyl-CoA semialdehyde:NADP+ oxidoreductase
4.1.2.44 2,3-epoxybenzoyl-CoA dihydrolase 2,3-epoxy-2,3-dihydrobenzoyl-CoA (3Z)-6-oxohex-3-enoyl-CoA-lyase (formate-forming)


Proteins

Protein ID name full name
Q84HH6 boxC Benzoyl-CoA-dihydrodiol lyase
Q84HH8 boxD 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase
Q9AIX6 boxA Benzoyl-CoA oxygenase component A
Q9AIX7 boxB Benzoyl-CoA oxygenase component B