Arg/N-end rule pathway (eukaryotic)

Hu RG, Sheng J, Qi X, Xu Z, Takahashi TT, Varshavsky A. The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators. Nature. 2005 Oct 13;437(7061):981–6. doi: 10.1038/nature04027. PMID: 16222293.; Hess DT, Matsumoto A, Kim S, Marshall HE, Stamler JS. Protein S-nitrosylation: purview and parameters. Nature Reviews Molecular Cell Biology. 2005 Feb 01;6(2):150–66. doi: 10.1038/nrm1569.

Metabolites

Cobalt ion

Formula: Co (58.933198)

CAS ID: 22541-53-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1



Enzyme

EC Number name full name note
2.3.1.254 N-terminal methionine Nalpha-acetyltransferase NatB acetyl-CoA:N-terminal Met-Asn/Gln/Asp/Glu-[protein] Met-Nalpha-acetyltransferase
2.3.2.8 arginyltransferase L-arginyl-tRNAArg:protein arginyltransferase
3.4.11.18 methionyl aminopeptidase
3.4.19.1 acylaminoacyl-peptidase
3.5.1.121 protein N-terminal asparagine amidohydrolase protein N-terminal asparagine amidohydrolase
3.5.1.122 protein N-terminal glutamine amidohydrolase protein N-terminal glutamine amidohydrolase


Proteins

Protein ID name full name