retinol biosynthesis

Blaner WS, Das SR, Gouras P, Flood MT. Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells. Journal of Biological Chemistry. 1987 Jan;262(1):53–8. doi: 10.1016/s0021-9258(19)75886-4.

Metabolites

beta-Carotene

Formula: C40H56 (536.4381776)

CAS ID: 7235-40-7

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Retinal

Formula: C20H28O (284.2140038)

CAS ID: 116-31-4

Retinol

Formula: C20H30O (286.229653)

CAS ID: 68-26-8

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.105 all-trans-retinol dehydrogenase (NAD+) all-trans retinol:NAD+ oxidoreductase
1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase 3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase
1.1.1.300 NADP-retinol dehydrogenase retinol:NADP+ oxidoreductase
1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase 3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase
1.13.11.63 beta-carotene 15,15'-dioxygenase beta-carotene:oxygen 15,15'-dioxygenase (bond-cleaving)
2.3.1.135 phosphatidylcholine-retinol O-acyltransferase phosphatidylcholine:retinol---[cellular-retinol-binding-protein] O-acyltransferase
3.1.1.1 carboxylesterase carboxylic-ester hydrolase
3.1.1.13 sterol esterase steryl-ester acylhydrolase
3.1.1.3 triacylglycerol lipase triacylglycerol acylhydrolase
3.1.1.56 methylumbelliferyl-acetate deacetylase 4-methylumbelliferyl-acetate acylhydrolase


Proteins

Protein ID name full name