methylthiopropanoate degradation I (cleavage)

Reisch CR, Stoudemayer MJ, Varaljay VA, Amster IJ, Moran MA, Whitman WB. Novel pathway for assimilation of dimethylsulphoniopropionate widespread in marine bacteria. Nature. 2011 May 12;473(7346):208–11. doi: 10.1038/nature10078. PMID: 21562561.

Metabolites

Acetaldehyde

Formula: C2H4O (44.0262134)

CAS ID: 75-07-0

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Methanethiol

Formula: CH4S (48.0033704)

CAS ID: 74-93-1

3-S-methylmercaptopropionate

Formula: C4H7O2S (119.0166742)

CAS ID:

3-(methylthio)propanoyl-CoA(4-)

Formula: C25H38N7O17P3S2 (865.0978408000001)

CAS ID:

3-(methylthio)acryloyl-CoA(4-)

Formula: C25H36N7O17P3S2 (863.0821916000001)

CAS ID:

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:



Enzyme

EC Number name full name note
1.3.99.41 3-(methylsulfanyl)propanoyl-CoA 2-dehydrogenase 3-(methylsulfanyl)propanoyl-CoA:acceptor 2-oxidoreductase
4.2.1.155 (methylthio)acryloyl-CoA hydratase 3-(methylsulfanyl)prop-2-enoyl-CoA hydro-lyase (acetaldehyde-forming)
6.2.1.44 3-(methylthio)propionyl-CoA ligase 3-(methylthio)propanoate:CoA ligase (AMP-forming)


Proteins

Protein ID name full name
Q5LLW6 dmdD Methylthioacryloyl-CoA hydratase
Q5LLW7 dmdC 3-methylmercaptopropionyl-CoA dehydrogenase
Q5LRT0 dmdB 3-methylmercaptopropionyl-CoA ligase