fatty acids biosynthesis (yeast)

Lomakin IB, Xiong Y, Steitz TA. The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together. Cell. 2007 Apr 20;129(2):319–32. doi: 10.1016/j.cell.2007.03.013. PMID: 17448991.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase (3R)-3-hydroxyacyl-[acyl-carrier protein]:NADP+ oxidoreductase
1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH) acyl-[acyl-carrier protein]:NAD+ oxidoreductase
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase acetyl-CoA:[acyl-carrier protein] S-acetyltransferase
2.3.1.39 [acyl-carrier-protein] S-malonyltransferase malonyl-CoA:[acyl-carrier protein] S-malonyltransferase
2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating)
2.3.1.86 fatty-acyl-CoA synthase system acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)
3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase oleoyl-[acyl-carrier protein] hydrolase
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] hydro-lyase (oct-2-enoyl-[acyl-carrier protein]-forming)


Proteins

Protein ID name full name
P07149 FAS1 Fatty acid synthase subunit beta
P19097 FAS2 Fatty acid synthase subunit alpha