Cholesterol biosynthesis II (via 24,25-dihydrolanosterol)

Itkin M, Heinig U, Tzfadia O, Bhide AJ, Shinde B, Cardenas PD, Bocobza SE, Unger T, Malitsky S, Finkers R, Tikunov Y, Bovy A, Chikate Y, Singh P, Rogachev I, Beekwilder J, Giri AP, Aharoni A. Biosynthesis of antinutritional alkaloids in solanaceous crops is mediated by clustered genes. Science. 2013 Jul 12;341(6142):175–9. doi: 10.1126/science.1240230. PMID: 23788733.; Ohyama K, Suzuki M, Kikuchi J, Saito K, Muranaka T. Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 2009 Jan 20;106(3):725–30. doi: 10.1073/pnas.0807675106.

Metabolites

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Lathosterol

Formula: C27H46O (386.3548466)

CAS ID: 80-99-9

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Presqualene diphosphate

Formula: C30H52O7P2 (586.3188102)

CAS ID: 29849-75-0

Squalene

Formula: C30H50 (410.39123)

CAS ID: 111-02-4

Zymosterol

Formula: C27H44O (384.3391974)

CAS ID: 128-33-6



Enzyme

EC Number name full name note


Proteins

Protein ID name full name