Pantothenate and CoA Biosynthesis
Metabolites
3-[[(2S)-2,4-Dihydroxy-3,3-dimethylbutanoyl]amino]propanoic acid
Formula: C9H17NO5 (219.11066720000002)
CAS ID: 37138-77-5
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.169 | 2-dehydropantoate 2-reductase | (R)-pantoate:NADP+ 2-oxidoreductase | |
| 1.1.1.86 | ketol-acid reductoisomerase (NADP+) | (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) | |
| 2.1.2.11 | 3-methyl-2-oxobutanoate hydroxymethyltransferase | 5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase | |
| 2.4.2.52 | triphosphoribosyl-dephospho-CoA synthase | ATP:3'-dephospho-CoA 5-triphospho-alpha-D-ribosyltransferase | |
| 2.7.1.24 | dephospho-CoA kinase | ATP:3'-dephospho-CoA 3'-phosphotransferase | |
| 2.7.1.33 | pantothenate kinase | ATP:(R)-pantothenate 4'-phosphotransferase | |
| 2.7.7.3 | pantetheine-phosphate adenylyltransferase | ATP:pantetheine-4'-phosphate adenylyltransferase | |
| 4.1.1.11 | aspartate 1-decarboxylase | L-aspartate 1-carboxy-lyase (beta-alanine-forming) | |
| 4.1.1.36 | phosphopantothenoylcysteine decarboxylase | N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming) | |
| 4.2.1.9 | dihydroxy-acid dehydratase | 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming) | |
| 6.3.2.1 | pantoate-beta-alanine ligase (AMP-forming) | (R)-pantoate:beta-alanine ligase (AMP-forming) | |
| 6.3.2.5 | phosphopantothenate-cysteine ligase (CTP) | (R)-4'-phosphopantothenate:L-cysteine ligase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P05791 | ilvD | Dihydroxy-acid dehydratase |
| P05793 | ilvC | Ketol-acid reductoisomerase (NADP(+)) |
| P0A6I3 | coaA | Pantothenate kinase |
| P0A6I6 | coaD | Phosphopantetheine adenylyltransferase |
| P0A6I9 | coaE | Dephospho-CoA kinase |
| P0A790 | panD | Aspartate 1-decarboxylase |
| P0A9J4 | panE | 2-dehydropantoate 2-reductase |
| P0ABQ0 | coaBC | Coenzyme A biosynthesis bifunctional protein CoaBC |
| P31057 | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase |
| P31663 | panC | Pantothenate synthetase |
| P77231 | citG | 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase |