Sepiapterin Reductase Deficiency

Metabolites

2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine

Formula: C9H18N5O14P3 (513.0063118)

CAS ID:

2,5-Diaminopyrimidine nucleoside triphosphate

Formula: C9H18N5O14P3 (513.0063118)

CAS ID:

7,8-Dihydroneopterin 3'-triphosphate

Formula: C9H16N5O13P3 (494.9957476)

CAS ID: 20574-65-6

Formamidopyrimidine nucleoside triphosphate

Formula: C10H18N5O15P3 (541.0012268)

CAS ID:

GTP

Formula: C10H16N5O14P3 (522.9906626)

CAS ID: 86-01-1

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

NAD+

Formula: C21H28N7O14P2 (664.1169428000001)

CAS ID: 53-84-9

NADH

Formula: C21H29N7O14P2 (665.1247674)

CAS ID: 58-68-4

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

Sepiapterin

Formula: C9H11N5O3 (237.0861856)

CAS ID: 17094-01-8

Triphosphate

Formula: H5P3O10 (257.909562)

CAS ID: 10380-08-2

1-hydroxy-2-Oxopropyl tetrahydropterin

Formula: C9H13N5O3 (239.1018348)

CAS ID:

D-Erythro-7,8-dihydrobiopterin

Formula: C9H13N5O3 (239.1018348)

CAS ID:



Enzyme

EC Number name full name note
1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) L-erythro-7,8-dihydrobiopterin:NADP+ oxidoreductase
1.1.1.184 carbonyl reductase (NADPH) secondary-alcohol:NADP+ oxidoreductase
1.1.1.189 prostaglandin-E2 9-reductase (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase
1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+) (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase
1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+) (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase
1.1.1.71 alcohol dehydrogenase [NAD(P)+] alcohol:NAD(P)+ oxidoreductase
4.2.3.12 6-pyruvoyltetrahydropterin synthase 7,8-dihydroneopterin 3'-triphosphate triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)


Proteins

Protein ID name full name