Prostaglandin and leukotriene metabolism in senescence

Lin Y, Xu Z. Fibroblast Senescence in Idiopathic Pulmonary Fibrosis. Front Cell Dev Biol. 2020;8():593283. PMID: 33324646; PMCID: PMC7723977.

Metabolites

15-Deoxy-Delta12,14-PGJ2

Formula: C20H28O3 (316.2038338)

CAS ID: 87893-55-8

3',5'-Cyclic AMP

Formula: C10H12N5O6P (329.0525182)

CAS ID: 60-92-4

4alpha-Methylzymosterol

Formula: C28H46O (398.3548466)

CAS ID: 7448-03-5

Adrenic acid

Formula: C22H36O2 (332.2715156)

CAS ID: 28874-58-0

Arachidonate

Formula: C20H32O2 (304.24021719999996)

CAS ID: 506-32-1

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Leukotriene A4

Formula: C20H30O3 (318.21948299999997)

CAS ID: 72059-45-1

Leukotriene B4

Formula: C20H32O4 (336.2300472)

CAS ID: 71160-24-2

Leukotriene C4

Formula: C30H47N3O9S (625.3032852)

CAS ID: 72025-60-6

Leukotriene D4

Formula: C25H40N2O6S (496.26069400000006)

CAS ID: 73836-78-9

Leukotriene E4

Formula: C23H37NO5S (439.23923120000006)

CAS ID: 75715-89-8

Prostaglandin D2

Formula: C20H32O5 (352.2249622)

CAS ID: 41598-07-6

Prostaglandin G2

Formula: C20H32O6 (368.2198772)

CAS ID: 51982-36-6

Prostaglandin H2

Formula: C20H32O5 (352.2249622)

CAS ID: 42935-17-1

Prostaglandin I2

Formula: C20H32O5 (352.2249622)

CAS ID: 35121-78-9

Thromboxane A2

Formula: C20H32O5 (352.2249622)

CAS ID: 57576-52-0

1a,1b-dihomo-15-deoxy-delta-12,14-PGJ2

Formula: C22H32O3 (344.23513219999995)

CAS ID:



Enzyme

EC Number name full name note
3.1.1.4 phospholipase A2 phosphatidylcholine 2-acylhydrolase
3.1.1.5 lysophospholipase 2-lysophosphatidylcholine acylhydrolase
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name