Peroxisomal protein import
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Revisiting the intraperoxisomal pathway of mammalian PEX7. Scientific Reports. 2015 Jul 03;5(1):11806. doi: 10.1038/srep11806.; Freitas MO, Francisco T, Rodrigues TA, Lismont C, Domingues P, Pinto MP, Grou CP, Fransen M, Azevedo JE. The peroxisomal protein import machinery displays a preference for monomeric substrates. Open Biol. 2015 Apr;5(4):140236. PMID: 25854684; PMCID: PMC4422123.; Fujiki Y, Okumoto K, Mukai S, Honsho M, Tamura S. Peroxisome biogenesis in mammalian cells. Front. Physiol. 2014 Aug 15;5(). doi: 10.3389/fphys.2014.00307.; Rodrigues TA, Alencastre IS, Francisco T, Brites P, Fransen M, Grou CP, Azevedo JE. A PEX7-Centered Perspective on the Peroxisomal Targeting Signal Type 2-Mediated Protein Import Pathway. Molecular and Cellular Biology. 2014 Aug 01;34(15):2917–28. doi: 10.1128/mcb.01727-13.; Lodhi IJ, Semenkovich CF. Peroxisomes: a nexus for lipid metabolism and cellular signaling. Cell Metab. 2014 Mar 04;19(3):380–92. 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Journal of Biological Chemistry. 2012 Apr;287(16):12815–27. doi: 10.1074/jbc.m112.340158.; Freitas MO, Francisco T, Rodrigues TA, Alencastre IS, Pinto MP, Grou CP, Carvalho AF, Fransen M, Sá-Miranda C, Azevedo JE. PEX5 Protein Binds Monomeric Catalase Blocking Its Tetramerization and Releases It upon Binding the N-terminal Domain of PEX14. Journal of Biological Chemistry. 2011 Nov;286(47):40509–19. doi: 10.1074/jbc.m111.287201.; Miyata N, Okumoto K, Mukai S, Noguchi M, Fujiki Y. AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase. Traffic. 2012 Jan;13(1):168–83. doi: 10.1111/j.1600-0854.2011.01298.x. PMID: 21980954.; Ma C, Agrawal G, Subramani S. Peroxisome assembly: matrix and membrane protein biogenesis. J Cell Biol. 2011 Apr 04;193(1):7–16. PMID: 21464226; PMCID: PMC3082194.; Meinecke M, Cizmowski C, Schliebs W, Krüger V, Beck S, Wagner R, Erdmann R. The peroxisomal importomer constitutes a large and highly dynamic pore. Nat Cell Biol. 2010 Mar;12(3):273–7. doi: 10.1038/ncb2027. PMID: 20154681.; Carvalho AF, Pinto MP, Grou CP, Alencastre IS, Fransen M, Sá-Miranda C, Azevedo JE. Ubiquitination of Mammalian Pex5p, the Peroxisomal Import Receptor. Journal of Biological Chemistry. 2007 Oct;282(43):31267–72. doi: 10.1074/jbc.m706325200.; Thoms S, Erdmann R. Peroxisomal matrix protein receptor ubiquitination and recycling. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2006 Dec;1763(12):1620–8. doi: 10.1016/j.bbamcr.2006.08.046.; Platta HW, Grunau S, Rosenkranz K, Girzalsky W, Erdmann R. Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol. Nat Cell Biol. 2005 Aug;7(8):817–22. doi: 10.1038/ncb1281. PMID: 16007078.; Oliveira ME, Gouveia AM, Pinto RA, Sá-Miranda C, Azevedo JE. The Energetics of Pex5p-mediated Peroxisomal Protein Import. Journal of Biological Chemistry. 2003 Oct;278(41):39483–8. doi: 10.1074/jbc.m305089200.; Reguenga C, Oliveira ME, Gouveia AM, Sá-Miranda C, Azevedo JE. Characterization of the mammalian peroxisomal import machinery: Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein assembly. J Biol Chem. 2001 Aug 10;276(32):29935–42. doi: 10.1074/jbc.m104114200. PMID: 11397814.; Otera H, Harano T, Honsho M, Ghaedi K, Mukai S, Tanaka A, Kawai A, Shimizu N, Fujiki Y. The Mammalian Peroxin Pex5pL, the Longer Isoform of the Mobile Peroxisome Targeting Signal (PTS) Type 1 Transporter, Translocates the Pex7p·PTS2 Protein Complex into Peroxisomes via Its Initial Docking Site, Pex14p. Journal of Biological Chemistry. 2000 Jul;275(28):21703–14. doi: 10.1074/jbc.m000720200.; Braverman N, Dodt G, Gould SJ, Valle D. An isoform of pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes. Hum Mol Genet. 1998 Aug;7(8):1195–205. doi: 10.1093/hmg/7.8.1195. PMID: 9668159.; Fransen M, Terlecky SR, Subramani S. Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import. Proc. Natl. Acad. Sci. U.S.A. 1998 Jul 07;95(14):8087–92. doi: 10.1073/pnas.95.14.8087.; Braverman N, Steel G, Obie C, Moser A, Moser H, Gould SJ, Valle D. Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata. Nat Genet. 1997 Apr;15(4):369–76. doi: 10.1038/ng0497-369. PMID: 9090381.; Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI. Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor. J Cell Biol. 1996 Oct;135(1):85–95. PMID: 8858165; PMCID: PMC2121023.; Walton PA, Hill PE, Subramani S. Import of stably folded proteins into peroxisomes. Mol Biol Cell. 1995 Jun;6(6):675–83. PMID: 7579687; PMCID: PMC301228.; Dodt G, Braverman N, Wong C, Moser A, Moser HW, Watkins P, Valle D, Gould SJ. Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders. Nat Genet. 1995 Feb;9(2):115–25. doi: 10.1038/ng0295-115. PMID: 7719337.; Swinkels BW, Gould SJ, Bodnar AG, Rachubinski RA, Subramani S. A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase. The EMBO Journal. 1991 Nov;10(11):3255–62. doi: 10.1002/j.1460-2075.1991.tb04889.x.; Gould SJ, Keller GA, Hosken N, Wilkinson J, Subramani S. A conserved tripeptide sorts proteins to peroxisomes. J Cell Biol. 1989 May;108(5):1657–64. PMID: 2654139; PMCID: PMC2115556.; Imanaka T, Small GM, Lazarow PB. Translocation of acyl-CoA oxidase into peroxisomes requires ATP hydrolysis but not a membrane potential. J Cell Biol. 1987 Dec;105(6 Pt 2):2915–22. PMID: 3693402; PMCID: PMC2114735.