Termination of translesion DNA synthesis

Park JM, Yang SW, Yu KR, Ka SH, Lee SW, Seol JH, Jeon YJ, Chung CH. Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis. Mol Cell. 2014 May 22;54(4):626–38. doi: 10.1016/j.molcel.2014.03.031. PMID: 24768535.; Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Nat Cell Biol. 2012 Oct;14(10):1089–98. doi: 10.1038/ncb2579. PMID: 23000965.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5



Enzyme

EC Number name full name note
3.1.11.-
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.7.7.7 DNA-directed DNA polymerase deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
3.4.19.12 ubiquitinyl hydrolase 1


Proteins

Protein ID name full name