Glucocorticoid biosynthesis

Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev. 2004 Dec;25(6):947–70. doi: 10.1210/er.2003-0030. PMID: 15583024.

Metabolites

11-Deoxycortisol

Formula: C21H30O4 (346.214398)

CAS ID: 152-58-9

17alpha-Hydroxypregnenolone

Formula: C21H32O3 (332.23513219999995)

CAS ID: 387-79-1

17alpha-Hydroxyprogesterone

Formula: C21H30O3 (330.21948299999997)

CAS ID: 68-96-2

Cortisol

Formula: C21H30O5 (362.209313)

CAS ID: 50-23-7

Cortisone

Formula: C21H28O5 (360.1936638)

CAS ID: 53-06-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Pregnenolone

Formula: C21H32O2 (316.24021719999996)

CAS ID: 145-13-1

pregn-5-ene-3,20-dione-17-ol

Formula: C21H30O3 (330.21948299999997)

CAS ID: 641-80-5

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase 3beta-hydroxy-DELTA5-steroid:NAD+ 3-oxidoreductase
1.14.14.16 steroid 21-monooxygenase steroid,NADPH-hemoprotein reductase:oxygen oxidoreductase (21-hydroxylating)
1.14.14.19 steroid 17alpha-monooxygenase steroid,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
1.14.14.32 17alpha-hydroxyprogesterone deacetylase 17alpha-hydroxyprogesterone,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing)
5.3.3.1 steroid DELTA-isomerase 3-oxosteroid DELTA5-DELTA4-isomerase


Proteins

Protein ID name full name