Regulation of RUNX2 expression and activity
Thacker G, Kumar Y, Khan MP, Shukla N, Kapoor I, Kanaujiya JK, Lochab S, Ahmed S, Sanyal S, Chattopadhyay N, Trivedi AK. Skp2 inhibits osteogenesis by promoting ubiquitin–proteasome degradation of Runx2. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2016 Apr;1863(4):510–9. doi: 10.1016/j.bbamcr.2016.01.010.; Yang F, Xu N, Li D, Guan L, He Y, Zhang Y, Lu Q, Zhang X. A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells. J Endod. 2014 Oct;40(10):1579–86. doi: 10.1016/j.joen.2014.04.010. PMID: 25260729.; Kammerer M, Gutzwiller S, Stauffer D, Delhon I, Seltenmeyer Y, Fournier B. Estrogen Receptor a (ERa) and Estrogen Related Receptor a (ERRa) are both transcriptional regulators of the Runx2-I isoform. Mol Cell Endocrinol. 2013 Apr 30;369(1-2):150–60. doi: 10.1016/j.mce.2013.01.024. PMID: 23403054.; Zhang YY, Li X, Qian SW, Guo L, Huang HY, He Q, Liu Y, Ma CG, Tang QQ. Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis. Mol Endocrinol. 2012 May;26(5):798–808. PMID: 22422618; PMCID: PMC5417096.; Yang D, Yang M, Tsai C, Huang T, Chen Y, Hung S. Hypoxia Inhibits Osteogenesis in Human Mesenchymal Stem Cells through Direct Regulation of RUNX2 by TWIST. PLoS ONE. 2011 Sep 09;6(9):e23965. doi: 10.1371/journal.pone.0023965.; Li X, Huang M, Zheng H, Wang Y, Ren F, Shang Y, Zhai Y, Irwin DM, Shi Y, Chen D, Chang Z. CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation. J Cell Biol. 2008 Jun 16;181(6):959–72. PMID: 18541707; PMCID: PMC2426947.; Li YL, Xiao ZS. Advances in Runx2 regulation and its isoforms. Med Hypotheses. 2007;68(1):169–75. doi: 10.1016/j.mehy.2006.06.006. PMID: 16901655.; Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Fariñas I, Karsenty G, Grosschedl R. SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell. 2006 Jun 02;125(5):971–86. doi: 10.1016/j.cell.2006.05.012. PMID: 16751105.; Jones DC, Wein MN, Oukka M, Hofstaetter JG, Glimcher MJ, Glimcher LH. Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science. 2006 May 26;312(5777):1223–7. doi: 10.1126/science.1126313. PMID: 16728642.; Lee MH, Kim YJ, Yoon WJ, Kim JI, Kim BG, Hwang YS, Wozney JM, Chi XZ, Bae SC, Choi KY, Cho JY, Choi JY, Ryoo HM. Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter. J Biol Chem. 2005 Oct 21;280(42):35579–87. doi: 10.1074/jbc.m502267200. PMID: 16115867.; Lengner CJ, Hassan MQ, Serra RW, Lepper C, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Nkx3.2-mediated Repression of Runx2 Promotes Chondrogenic Differentiation. Journal of Biological Chemistry. 2005 Apr;280(16):15872–9. doi: 10.1074/jbc.m411144200.; Bialek P, Kern B, Yang X, Schrock M, Sosic D, Hong N, Wu H, Yu K, Ornitz DM, Olson EN, Justice MJ, Karsenty G. A twist code determines the onset of osteoblast differentiation. Dev Cell. 2004 Mar;6(3):423–35. doi: 10.1016/s1534-5807(04)00058-9. PMID: 15030764.; Kim S, Koga T, Isobe M, Kern BE, Yokochi T, Chin YE, Karsenty G, Taniguchi T, Takayanagi H. Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. Genes Dev. 2003 Aug 15;17(16):1979–91. PMID: 12923053; PMCID: PMC196253.; Zhao M, Qiao M, Oyajobi BO, Mundy GR, Chen D. E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation. J Biol Chem. 2003 Jul 25;278(30):27939–44. doi: 10.1074/jbc.m304132200. PMID: 12738770.; Yoshida CA, Furuichi T, Fujita T, Fukuyama R, Kanatani N, Kobayashi S, Satake M, Takada K, Komori T. Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet. 2002 Dec;32(4):633–8. doi: 10.1038/ng1015. PMID: 12434152.; Kundu M, Javed A, Jeon JP, Horner A, Shum L, Eckhaus M, Muenke M, Lian JB, Yang Y, Nuckolls GH, Stein GS, Liu PP. Cbfbeta interacts with Runx2 and has a critical role in bone development. Nat Genet. 2002 Dec;32(4):639–44. doi: 10.1038/ng1050. PMID: 12434156.; Robledo RF, Rajan L, Li X, Lufkin T. The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development. Genes Dev. 2002 May 01;16(9):1089–101. doi: 10.1101/gad.988402.; Otto F, Kanegane H, Mundlos S. Mutations in the RUNX2 gene in patients with cleidocranial dysplasia. Hum Mutat. 2002 Mar;19(3):209–16. doi: 10.1002/humu.10043. PMID: 11857736.; Drissi H, Luc Q, Shakoori R, Chuva De Sousa Lopes S, Choi JY, Terry A, Hu M, Jones S, Neil JC, Lian JB, Stein JL, Van Wijnen AJ, Stein GS. Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene. J Cell Physiol. 2000 Sep;184(3):341–50. doi: 10.1002/1097-4652(200009)184:3<341::aid-jcp8>3.0.co;2-z. PMID: 10911365.; Tribioli C, Lufkin T. The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen. Development. 1999 Dec;126(24):5699–711. doi: 10.1242/dev.126.24.5699. PMID: 10572046.; Ducy P, Starbuck M, Priemel M, Shen J, Pinero G, Geoffroy V, Amling M, Karsenty G. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes & Development. 1999 Apr 15;13(8):1025–36. doi: 10.1101/gad.13.8.1025.