Activation of Matrix Metalloproteinases

Rodríguez D, Morrison CJ, Overall CM. Matrix metalloproteinases: What do they not do? New substrates and biological roles identified by murine models and proteomics. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2010 Jan;1803(1):39–54. doi: 10.1016/j.bbamcr.2009.09.015.; Butler GS, Overall CM. Updated biological roles for matrix metalloproteinases and new 'intracellular' substrates revealed by degradomics. Biochemistry. 2009 Nov 24;48(46):10830–45. doi: 10.1021/bi901656f. PMID: 19817485.; Morrison CJ, Butler GS, Rodríguez D, Overall CM. Matrix metalloproteinase proteomics: substrates, targets, and therapy. Curr Opin Cell Biol. 2009 Oct;21(5):645–53. doi: 10.1016/j.ceb.2009.06.006. PMID: 19616423.; Cauwe B, Van den Steen PE, Opdenakker G. The Biochemical, Biological, and Pathological Kaleidoscope of Cell Surface Substrates Processed by Matrix Metalloproteinases. Critical Reviews in Biochemistry and Molecular Biology. 2007 Jan;42(3):113–85. doi: 10.1080/10409230701340019.

Metabolites



Enzyme

EC Number name full name note
3.4.24.-
3.4.21.75 Furin
3.4.24.17 stromelysin 1
3.4.24.23 matrilysin
3.4.24.24 gelatinase A
3.4.24.34 neutrophil collagenase
3.4.24.35 gelatinase B
3.4.24.7 interstitial collagenase
3.4.24.80 membrane-type matrix metalloproteinase-1


Proteins

Protein ID name full name