SUMOylation of transcription factors

Lomelí H, Vázquez M. Emerging roles of the SUMO pathway in development. Cellular and Molecular Life Sciences. 2011 Sep 04;68(24):4045–64. doi: 10.1007/s00018-011-0792-5.; Garcia-Dominguez M, Reyes JC. SUMO association with repressor complexes, emerging routes for transcriptional control. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2009 Jun;1789(6-8):451–9. doi: 10.1016/j.bbagrm.2009.07.001.; Ouyang J, Valin A, Gill G. Regulation of transcription factor activity by SUMO modification. Methods Mol Biol. 2009;497():141–52. doi: 10.1007/978-1-59745-566-4_9. PMID: 19107415.; Lyst MJ, Stancheva I. A role for SUMO modification in transcriptional repression and activation. Biochem Soc Trans. 2007 Dec;35(Pt 6):1389–92. PMID: 18031228; PMCID: PMC2871292.; Gill G. Something about SUMO inhibits transcription. Current Opinion in Genetics & Development. 2005 Oct;15(5):536–41. doi: 10.1016/j.gde.2005.07.004.; Girdwood DWH, Tatham MH, Hay RT. SUMO and transcriptional regulation. Seminars in Cell & Developmental Biology. 2004 Apr;15(2):201–10. doi: 10.1016/j.semcdb.2003.12.001.

Metabolites



Enzyme

EC Number name full name note
2.3.2.-
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)


Proteins

Protein ID name full name