DNA Damage Recognition in GG-NER

Oh K, Imoto K, Emmert S, Tamura D, DiGiovanna JJ, Kraemer KH. Nucleotide Excision Repair Proteins Rapidly Accumulate but Fail to Persist in Human XP-E (DDB2 Mutant) Cells. Photochem & Photobiology. 2011 Mar 09;87(3):729–33. doi: 10.1111/j.1751-1097.2011.00909.x.; Camenisch U, Träutlein D, Clement FC, Fei J, Leitenstorfer A, Ferrando-May E, Naegeli H. Two-stage dynamic DNA quality check by xeroderma pigmentosum group C protein. EMBO J. 2009 Aug 19;28(16):2387–99. PMID: 19609301; PMCID: PMC2735174.; Moser J, Volker M, Kool H, Alekseev S, Vrieling H, Yasui A, van Zeeland AA, Mullenders LH. The UV-damaged DNA binding protein mediates efficient targeting of the nucleotide excision repair complex to UV-induced photo lesions. DNA Repair (Amst). 2005 May 02;4(5):571–82. doi: 10.1016/j.dnarep.2005.01.001. PMID: 15811629.; Wang QE, Zhu Q, Wani G, Chen J, Wani AA. UV radiation-induced XPC translocation within chromatin is mediated by damaged-DNA binding protein, DDB2. Carcinogenesis. 2004 Jun;25(6):1033–43. doi: 10.1093/carcin/bgh085. PMID: 14742321.; Fitch ME, Nakajima S, Yasui A, Ford JM. In Vivo Recruitment of XPC to UV-induced Cyclobutane Pyrimidine Dimers by the DDB2 Gene Product. Journal of Biological Chemistry. 2003 Nov;278(47):46906–10. doi: 10.1074/jbc.m307254200.

Metabolites

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
3.4.-.-
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.3.2.32 cullin-RING-type E3 NEDD8 transferase [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine:[cullin] [NEDD8-protein] transferase (isopeptide bond-forming; RING-type)
3.6.4.12 DNA helicase


Proteins

Protein ID name full name