Regulation by c-FLIP

Toivonen HT, Meinander A, Asaoka T, Westerlund M, Pettersson F, Mikhailov A, Eriksson JE, Saxén H. Modeling Reveals That Dynamic Regulation of c-FLIP Levels Determines Cell-to-Cell Distribution of CD95-mediated Apoptosis. Journal of Biological Chemistry. 2011 May;286(21):18375–82. doi: 10.1074/jbc.m110.177097.; Pop C, Oberst A, Drag M, Van Raam BJ, Riedl SJ, Green DR, Salvesen GS. FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity. Biochem J. 2011 Feb 01;433(3):447–57. PMID: 21235526; PMCID: PMC4024219.; Haag C, Stadel D, Zhou S, Bachem MG, Möller P, Debatin K, Fulda S. Identification of c-FLIP L and c-FLIP S as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells. Gut. 2010 Sep 28;60(2):225–37. doi: 10.1136/gut.2009.202325.; Fricker N, Beaudouin J, Richter P, Eils R, Krammer PH, Lavrik IN. Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL. J Cell Biol. 2010 Aug 09;190(3):377–89. PMID: 20696707; PMCID: PMC2922645.; Yu JW, Jeffrey PD, Shi Y. Mechanism of procaspase-8 activation by c-FLIP L. Proc. Natl. Acad. Sci. U.S.A. 2009 May 19;106(20):8169–74. doi: 10.1073/pnas.0812453106.; Golks A, Brenner D, Fritsch C, Krammer PH, Lavrik IN. c-FLIPR, a New Regulator of Death Receptor-induced Apoptosis. Journal of Biological Chemistry. 2005 Apr;280(15):14507–13. doi: 10.1074/jbc.m414425200.; Scaffidi C, Schmitz I, Krammer PH, Peter ME. The Role of c-FLIP in Modulation of CD95-induced Apoptosis. Journal of Biological Chemistry. 1999 Jan;274(3):1541–8. doi: 10.1074/jbc.274.3.1541.; Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES. FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis. Journal of Biological Chemistry. 1997 Jul;272(30):18542–5. doi: 10.1074/jbc.272.30.18542.; Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schröter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J. Inhibition of death receptor signals by cellular FLIP. Nature. 1997 Jul 10;388(6638):190–5. doi: 10.1038/40657. PMID: 9217161.; Shu HB, Halpin DR, Goeddel DV. Casper is a FADD- and caspase-related inducer of apoptosis. Immunity. 1997 Jun;6(6):751–63. doi: 10.1016/s1074-7613(00)80450-1. PMID: 9208847.

Metabolites



Enzyme

EC Number name full name note
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.4.22.61 caspase-8


Proteins

Protein ID name full name