RNA Polymerase II Transcription Initiation

Kugel JF, Goodrich JA. Translocation after Synthesis of a Four-Nucleotide RNA Commits RNA Polymerase II to Promoter Escape. Molecular and Cellular Biology. 2002 Feb 01;22(3):762–73. doi: 10.1128/mcb.22.3.762-773.2002.; Holstege FC, Fiedler U, Timmers HT. Three transitions in the RNA polymerase II transcription complex during initiation. EMBO J. 1997 Dec 15;16(24):7468–80. PMID: 9405375; PMCID: PMC1170346.; Holstege FC, van der Vliet PC, Timmers HT. Opening of an RNA polymerase II promoter occurs in two distinct steps and requires the basal transcription factors IIE and IIH. The EMBO Journal. 1996 Apr;15(7):1666–77. doi: 10.1002/j.1460-2075.1996.tb00512.x.; Zawel L, Kumar KP, Reinberg D. Recycling of the general transcription factors during RNA polymerase II transcription. Genes Dev. 1995 Jun 15;9(12):1479–90. doi: 10.1101/gad.9.12.1479. PMID: 7601352.; Luse DS, Jacob GA. Abortive initiation by RNA polymerase II in vitro at the adenovirus 2 major late promoter. Journal of Biological Chemistry. 1987 Nov;262(31):14990–7. doi: 10.1016/s0021-9258(18)48127-6.

Metabolites



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
5.6.2.4 DNA 3'-5' helicase DNA 3'-5' helicase (ATP-hydrolysing)


Proteins

Protein ID name full name