Cysteine formation from homocysteine

Bearden SE, Beard RS, Pfau JC. Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stress. American Journal of Physiology-Heart and Circulatory Physiology. 2010 Nov;299(5):H1568–76. doi: 10.1152/ajpheart.00555.2010.; Dominy JE, Stipanuk MH. New roles for cysteine and transsulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant. Nutr Rev. 2004 Sep;62(9):348–53. doi: 10.1111/j.1753-4887.2004.tb00060.x. PMID: 15497768.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

2-oxobutanoate

Formula: C4H5O3 (101.02386800000001)

CAS ID:



Enzyme

EC Number name full name note
4.2.1.22 cystathionine beta-synthase L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
4.4.1.1 cystathionine gamma-lyase L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)
4.4.1.2 homocysteine desulfhydrase L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)


Proteins

Protein ID name full name