Base Excision Repair

Sokhansanj BA, Rodrigue GR, Fitch JP, Wilson DM. A quantitative model of human DNA base excision repair. I. Mechanistic insights. Nucleic Acids Res. 2002 Apr 15;30(8):1817–25. PMID: 11937636; PMCID: PMC113225.; Lindahl T, Wood RD. Quality control by DNA repair. Science. 1999 Dec 03;286(5446):1897–905. doi: 10.1126/science.286.5446.1897. PMID: 10583946.

Metabolites

4,6-Diamino-5-formamidopyrimidine

Formula: C5H7N5O (153.0650572)

CAS ID: 5122-36-1

5,6-Dihydrouracil

Formula: C4H6N2O2 (114.04292559999999)

CAS ID: 504-07-4

Adenine

Formula: C5H5N5 (135.054493)

CAS ID: 73-24-5

ADP-D-ribose

Formula: C15H23N5O14P2 (559.0716718)

CAS ID:

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

Thymine

Formula: C5H6N2O2 (126.04292559999999)

CAS ID: 65-71-4

Uracil

Formula: C4H4N2O2 (112.02727639999999)

CAS ID: 66-22-8

Thymine glycol

Formula: C5H8N2O4 (160.0484048)

CAS ID: 2943-56-8

1,N6-Ethenoadenine

Formula: C7H5N5 (159.054493)

CAS ID: 13875-63-3

5-Hydroxyuracil

Formula: C4H4N2O3 (128.0221914)

CAS ID: 20636-41-3

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

3,N(4)-ethenocytosine

Formula: C6H5N3O (135.04326)

CAS ID: 55662-66-3

cytosine glycol

Formula: C4H7N3O3 (145.0487392)

CAS ID: 13484-98-5

2,6-diamino-5-formamido-4-hydroxypyrimidine

Formula: C5H7N5O2 (169.05997220000003)

CAS ID: 133310-38-0

spiroiminodihydantoin

Formula: C5H5N5O3 (183.039238)

CAS ID: 480996-13-2

5-guanidinohydantoin

Formula: C4H7N5O2 (157.0599722)

CAS ID: 104184-01-2



Enzyme

EC Number name full name note
2.4.2.-
2.4.2.30 NAD+ ADP-ribosyltransferase NAD+:poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
2.7.7.7 DNA-directed DNA polymerase deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
3.1.11.2 exodeoxyribonuclease III
3.2.1.143 poly(ADP-ribose) glycohydrolase
4.2.99.18 DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase


Proteins

Protein ID name full name